Evaluation of involvement of axillary lymph nodes with Ki-67 expression in patients with breast cancer

Asadi, M. and Ziaeemehr, A. and Shahidsales, S. and Aledavood, S. A. and Anvari, K. and Mirsadraee, M. and Nemati, M. and Avan, A. and Aghel, E. (2018) Evaluation of involvement of axillary lymph nodes with Ki-67 expression in patients with breast cancer. International Journal of Cancer Management, 11 (8).

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Background: Breast cancer is the first leading cause of cancer-related deaths in women. Ki-67 is being used for evaluation of the prognosis of patients with breast cancer. Objectives: The aim of the current study was to explore the association of the involvement of axillary lymph nodes status with the expression of Ki-67 in patients with breast cancer. Methods: A total of 449 patients were enrolled followed by evaluation of the association of Ki67 levels with demographic, pathologic, and survival data of patients, using Chi-square, logistic regression models, student t test and Mann-Whitney. Results: We observed a significant relationship between the expression level of Ki-67 and stage of tumor (P = 0.012), positive progesterone receptor (P = 0.003), and subtype pathologic features (P < 0.05). Also, a significant difference was detected between Her2 and expression level of Ki-67 (P = 0.015). Survival analysis showed the association for Ki-67 (P = 0.02), age (P = 0.005), stage of tumor (P < 0.05), lymph node involvement (P = 0.001), and the Her2 (P = 0.024) with clinical outcome (e.g., overall survival or disease free survival) of patients with breast cancer. Conclusions: The results of this study demonstrated that the overexpression of Ki-67 was associated with large tumors, progesterone receptor expression, and stage of tumor, but it was not related with lymph node involvement. © 2018, Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Shahidsales, S.; Cancer Research Center, Mashhad University of Medical SciencesIran; email: shahidsaless@mums.ac.ir
Uncontrolled Keywords: Breast cancer Ki-67 Lymph node involvement epidermal growth factor receptor 2 estrogen receptor Ki 67 antigen progesterone adult Article cancer prognosis cancer staging cell proliferation clinical outcome disease free survival distant metastasis female follow up gene expression human human tissue lobular carcinoma major clinical study middle aged overall survival protein expression retrospective study tumor volume
Subjects: WH Hemic and Lymphatic System
WP Gynecology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 06 Jun 2020 07:53
Last Modified: 06 Jun 2020 07:53
URI: http://eprints.mums.ac.ir/id/eprint/17206

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