The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

Asadi, S. and Roohbakhsh, A. and Shamsizadeh, A. and Fereidoni, M. and Kordijaz, E. and Moghimi, A. (2018) The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats. BMC Neuroscience, 19 (1).

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The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats.pdf

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Abstract

Background: Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known experimental model for epileptic seizures. The purpose of this study was to evaluate the effect of Orx2 receptor antagonist (TCS OX2 29) on seizures and anxiety of PTZ-kindled rats. Results: Our results revealed that similar to valproate, administration of 7μg/rat of TCS OX2 29 increased the latency period and decreased the duration time of 3rd and 4th stages of epileptiform seizures. Besides, it significantly decreased mean of seizure scores. However, TCS OX2 29 did not modulate anxiety induced by repeated PTZ administration. Conclusion: This study showed that blockade of Orx2 receptor reduced seizure-related behaviors without any significant effect on PTZ-induced anxiety. © 2018 The Author(s).

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 CODEN: BNMEA Correspondence Address: Moghimi, A.; Ferdowsi University of Mashhad, Department of Biology, Rayan Center for Neuroscience and Behavior, Faculty of Science, P.O. Box 9177948974, Iran; email: moghimi@um.ac.ir
Uncontrolled Keywords: Anxiety Kindling Orexin Orx2 receptor PTZ Seizure 1 (3,4 dihydro 6,7 dimethoxy 2(1h) isoquinolinyl) 3,3 dimethyl 2 (4 pyridinylmethyl)amino 1 butanone orexin 2 receptor pentetrazole valproic acid anticonvulsive agent convulsant agent orexin receptor antagonist adult animal experiment animal model animal tissue Article controlled study disease severity drug effect epilepsy kindled seizure latent period male nonhuman rat seizure score Wistar rat animal animal behavior brain drug therapy Animals Anticonvulsants Behavior, Animal Convulsants Kindling, Neurologic Orexin Receptor Antagonists Pentylenetetrazole Rats, Wistar
Subjects: WL Nervous system
WM Psychiatry
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 06 Jun 2020 07:56
Last Modified: 06 Jun 2020 07:56
URI: http://eprints.mums.ac.ir/id/eprint/17207

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