Changes in health-related quality of life in oesophagogastric cancer patients participating in palliative and curative therapies

Asadi-Lari, M. and Homaee-Shandiz, F. and Esmaeili-Hesari, A. (2018) Changes in health-related quality of life in oesophagogastric cancer patients participating in palliative and curative therapies. Medical Journal of the Islamic Republic of Iran, 32 (1). pp. 182-190.

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Abstract

Background: Various treatments are used to prolong survival and improve quality of life (QOL). The purpose of this study was to assess the change in QOL scores in patients with Oesophagogastric (OG) cancer undergoing curative intent and palliative therapy. Methods: This was a mix-designed cohort study with a consecutive sampling of patients with OG cancer who underwent curative or palliative treatment regimens. The QOL, as a determinant of efficacy and impact of cancer care, was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires. QOL data were collected from the eligible subjects at three points of time. The repeated measurement test was used to compare the significance of change in scores. Results: Overall, 149 patients (54.4 male, 61.1 curative intent, 52.3 esophageal, 37.6 gastric, 10.1 OG junction cancer; with mean age 62 year) with OG cancer were eligible for inclusion in the study. Compared to the palliative group, the curative group was more likely to have an esophageal tumor site, Squamous Cell Carcinoma, and stage 2 (versus stomach, Adenocarcinoma, and stage 4 in the palliative group). In comparing the patients' functional, global health status, and cancer symptom, considering time, group of treatment, and their mutual effect the result indicated significant difference between the intervention groups. Conclusion: Most patients with Oesophagogastric cancer are diagnosed with an incurable form of the disease. Hence in absence of curative treatment, palliative therapy is the most effective therapy to maintain patient independency and relieve pain and symptom in order to improve their QOL. The present study has shown that palliative similar to curative intervention can improve the QOL in cancer patient especially in short term. © Iran University of Medical Sciences.

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: MJIIE Correspondence Address: Esmaeili-Hesari, A.; Social Determinants of Health Research Center, Mashhad University of Medical SciencesIran; email: esmaeilia1@mums.ac.ir
Uncontrolled Keywords: EORTC QLQ-C30 EORTC QLQ-OG25 Health-related quality of life Iran Oesophagogastric cancer Repeated measurement analysis
Subjects: WA Public Health
WI Digestive System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 06 Jun 2020 08:10
Last Modified: 06 Jun 2020 08:10
URI: http://eprints.mums.ac.ir/id/eprint/17208

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