Long-acting somatostatin analog therapy differentially alters 68 Ga-DOTATATE uptake in normal tissues compared with primary tumors and metastatic lesions

Ayati, N. and Lee, S. T. and Zakavi, R. and Pathmaraj, K. and Al-Qatawna, L. and Poon, A. and Scott, A. M. (2018) Long-acting somatostatin analog therapy differentially alters 68 Ga-DOTATATE uptake in normal tissues compared with primary tumors and metastatic lesions. Journal of Nuclear Medicine, 59 (2). pp. 223-227.

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Long-acting somatostatin analog therapy differentially alters 68 Ga-DOTATATE uptake in normal tissues compared with primary tumors and metastatic lesions.pdf

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Abstract

Synthetic somatostatin analogs have been posed as a potential source of error in somatostatin receptor imaging through interference with tumor detection; however, experimental models and clinical studies have shown a complex mechanism of the effect of octreotide on tumors. The aim of this study was to assess whether 68 Ga-DOTATATE uptake before treatment with long-acting somatostatin analogs differs from that after treatment. Methods: Thirty patients (15 men; age mean 6 SD, 64.6 6 13.4 y) who had intermediately differentiated to well-differentiated neuroendocrine tumors and who underwent 68 Ga-DOTATATE PET/CT scanning before and after receiving long-acting repeatable octreotide (Sandostatin LAR) were included in the study. The SUV max and SUV mean of healthy target organs, residual primary tumor, and up to 5 lesions with the highest SUV max in each organ were compared before and after octreotide treatment. Results: The mean time interval between the 2 68 Ga-DOTATATE studies was 9.6 6 7.2 mo, and the mean time gap between the last Sandostatin LAR injection and the second 68 Ga-DOTATATE study was 25.1 6 14.8 d. The pretreatment mean SUV max and SUV mean were both significantly higher in the thyroid, liver, and spleen (P, 0.05) than the values measured after the administration of Sandostatin LAR. No significant differences were found among the uptake indices for residual primary tumor or any metastatic lesions in the liver, bone, lung, or lymph nodes before and after Sandostatin LAR administration (P . 0.05). Conclusion: Long-acting octreotide treatment diminished 68 Ga-DOTATATE uptake in the liver, spleen, and thyroid but did not compromise tracer uptake in residual primary tumor and metastatic lesions. These findings have a direct impact on the interpretation of 68 Ga-DOTATATE PET/CT scans. © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 CODEN: JNMEA Correspondence Address: Scott, A.M.; Department of Molecular Imaging and Therapy, Austin Health, 145 Studley Rd., Australia; email: andrew.scott@austin.org.au
Uncontrolled Keywords: 68Ga-DOTATATE Neuroendocrine tumor Octreotide Somatostatin analogs Somatostatin receptor imaging gallium dotatate ga 68 Ki 67 antigen dotatate gallium ga-68 organometallic compound somatostatin adnexa metastasis adult aged Article bone metastasis cancer grading clinical article drug antagonism drug effect drug uptake female female genital tract cancer human liver liver metastasis lung metastasis lymph node metastasis male metastasis pancreas metastasis positron emission tomography-computed tomography primary tumor priority journal spleen thyroid gland tumor differentiation artifact chemistry diagnostic imaging metabolism middle aged pathology transport at the cellular level Artifacts Biological Transport Humans Neoplasm Metastasis Neuroendocrine Tumors Organometallic Compounds Positron Emission Tomography Computed Tomography
Subjects: WN Radiology . Diagnostic Imaging
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 08 Jun 2020 04:56
Last Modified: 08 Jun 2020 04:56
URI: http://eprints.mums.ac.ir/id/eprint/17215

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