Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

Baghcheghi, Y. and Hosseini, M. and Beheshti, F. and Salmani, H. and Anaeigoudari, A. (2018) Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats. Arquivos de Neuro-Psiquiatria, 76 (1). pp. 32-40.

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Abstract

In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats. © 2018, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 CODEN: ANPIA Correspondence Address: Anaeigoudari, A.; Department of Physiology, School of Medicine, Jiroft University of medical SciencesIran; email: Anaeiga317@gmail.com
Uncontrolled Keywords: Hypothyroidism Memory Propylthiouracil malonaldehyde nitric oxide thymoquinone antioxidant antithyroid agent benzoquinone derivative catalase superoxide dismutase amygdala animal experiment animal model animal tissue Article colorimetry controlled study enzymatic assay goiter hippocampus lipid peroxidation memory disorder Morris water maze test nonhuman oxidative stress passive avoidance test radioimmunoassay rat animal avoidance behavior brain injury chemically induced complication disease model drug effect learning disorder male maze test metabolism Wistar rat Animals Antioxidants Antithyroid Agents Avoidance Learning Benzoquinones Brain Injuries Disease Models, Animal Learning Disorders Malondialdehyde Maze Learning Memory Disorders Rats, Wistar
Subjects: WK Endocrine System
WL Nervous system
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 06 Jun 2020 06:15
Last Modified: 06 Jun 2020 06:15
URI: http://eprints.mums.ac.ir/id/eprint/17221

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