Therapeutic potency of pharmacological adenosine receptor agonist/antagonist in angiogenesis, current status and perspectives

Bahreyni, A. and Khazaei, M. and Rajabian, M. and Ryzhikov, M. and Avan, A. and Hassanian, S. M. (2018) Therapeutic potency of pharmacological adenosine receptor agonist/antagonist in angiogenesis, current status and perspectives. Journal of Pharmacy and Pharmacology, 70 (2). pp. 191-196.

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Objectives: Adenosine concentration significantly increases in tumour microenvironment contributing to tumorigenic processes including cell proliferation, survival, invasion and of special interest in this review angiogenesis. Key findings: This review summarizes the role of pharmacological adenosine receptor agonist and antagonist in regulating angiogenesis for a better understanding and hence a better management of angiogenesis-associated disorders. Summary: Depending upon the pharmacological characteristics of adenosine receptor subtypes, adenosine elicits anti- or pro-angiogenic responses in stimulated cells. Inhibition of the stimulatory effect of adenosine signalling on angiogenesis using specific pharmacological adenosine receptor agonist, and antagonist is a potentially novel strategy to suppress angiogenesis in tumours. © 2017 Royal Pharmaceutical Society

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 CODEN: JPPMA Correspondence Address: Avan, A.; Metabolic Syndrome Research Center, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: adenosine adenosine receptors angiogenesis receptor agonist/antagonist adenosine A1 receptor adenosine A2 receptor adenosine receptor blocking agent adenosine receptor stimulating agent adenosine receptor angiogenesis inhibitor angiogenic factor antiangiogenic activity cancer inhibition carcinogenic activity cell invasion cell proliferation cell survival concentration (parameters) disease association down regulation drug activation drug effect drug mechanism drug response human nonhuman protein expression Review signal transduction therapy effect tumor microenvironment animal metabolism neoplasm neovascularization (pathology) pathology Angiogenesis Inducing Agents Angiogenesis Inhibitors Animals Humans Neoplasms Neovascularization, Pathologic Purinergic P1 Receptor Agonists Purinergic P1 Receptor Antagonists Receptors, Purinergic P1
Subjects: QV pharmacology
QW Microbiology and Immunology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 26 May 2020 08:07
Last Modified: 26 May 2020 08:07

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