Bioactive glasses: Where are we and where are we going?

Baino, F. and Hamzehlou, S. and Kargozar, S. (2018) Bioactive glasses: Where are we and where are we going? Journal of Functional Biomaterials, 9 (1).

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Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of biologically-active ions. 45S5-based glass products have been successfully implanted in millions of patients worldwide, mainly to repair bone and dental defects and, over the years, many other bioactive glass compositions have been proposed for innovative biomedical applications, such as soft tissue repair and drug delivery. The full potential of bioactive glasses seems still yet to be fulfilled, and many of today's achievements were unthinkable when research began. As a result, the research involving bioactive glasses is highly stimulating and requires a cross-disciplinary collaboration among glass chemists, bioengineers, and clinicians. The present article provides a picture of the current clinical applications of bioactive glasses, and depicts six relevant challenges deserving to be tackled in the near future. We hope that this work can be useful to both early-stage researchers, who are moving with their first steps in the world of bioactive glasses, and experienced scientists, to stimulate discussion about future research and discover new applications for glass in medicine. © 2018 by the authors.

Item Type: Article
Additional Information: Cited By :55 Export Date: 16 February 2020 Correspondence Address: Baino, F.; Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, Italy; email:
Uncontrolled Keywords: Angiogenesis Bioglass Coating Drug delivery In vitro In vivo Ion release Mesoporous bioactive glasses Scaffold Tissue engineering biomaterial divalent cation hydroxyapatite monovalent cation bioactive glass bone development bone remodeling human in vitro study in vivo study medical research methodology nonhuman regenerative medicine Review scientist soft tissue tissue regeneration wound healing
Subjects: QT physiology
QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 26 May 2020 08:20
Last Modified: 26 May 2020 08:20

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