The benefits of folic acid-modified gold nanoparticles in CT-based molecular imaging: radiation dose reduction and image contrast enhancement

Beik, J. and Jafariyan, M. and Montazerabadi, A. and Ghadimi-Daresajini, A. and Tarighi, P. and Mahmoudabadi, A. and Ghaznavi, H. and Shakeri-Zadeh, A. (2018) The benefits of folic acid-modified gold nanoparticles in CT-based molecular imaging: radiation dose reduction and image contrast enhancement. Artificial Cells, Nanomedicine and Biotechnology, 46 (8). pp. 1993-2001.

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X-ray computed tomography (CT) requires an optimal compromise between image quality and patient dose. While high image quality is an important requirement in CT, the radiation dose must be kept minimal to protect the patients from ionizing radiation-associated risks. The use of probes based on gold nanoparticles (AuNPs) along with active targeting ligands for specific recognition of cancer cells may be one of the balanced solutions. Herein, we report the effect of folic acid (FA)-modified AuNP as a targeted nanoprobe on the contrast enhancement of CT images as well as its potential for patient dose reduction. For this purpose, nasopharyngeal KB cancer cells overexpressing FA receptors were incubated with AuNPs with and without FA modification and imaged in a CT scanner with the following X-ray tube parameters: peak tube voltage of 130 KVp, and tube current–time products of 60, 90, 120, 160 and 250 mAs. Moreover, in order to estimate the radiation dose to which the patient was exposed during a head CT protocol, the CT dose index (CTDI) value was measured by an X-ray electrometer by changing the tube current–time product. Raising the tube current–time product from 60 to 250 mAs significantly increased the absorbed dose from 18 mGy to 75 mGy. This increase was not associated with a significant enhancement of the image quality of the KB cells. However, an obvious increase in image brightness and CT signal intensity (quantified by Hounsfield units HU) were observed in cells exposed to nanoparticles without any increase in the mAs product or radiation dose. Under the same Au concentration, KB cells exposed to FA-modified AuNPs had significantly higher HU and brighter CT images than those of the cells exposed to AuNPs without FA modification. In conclusion, FA-modified AuNP can be considered as a targeted CT nanoprobe with the potential for dose reduction by keeping the required mAs product as low as possible while enhancing image contrast. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :18 Export Date: 16 February 2020 Correspondence Address: Shakeri-Zadeh, A.; Department of Medical Physics, School of Medicine, Iran University of medical Sciences (IUMS), Hemmat Exp. Way, Iran; email:
Uncontrolled Keywords: CT dose index folic acid gold nanoparticles image contrast molecular imaging X-ray computed tomography Cells Cytology Diseases Dosimetry Fiber optic sensors Image enhancement Image quality Ionizing radiation Metal nanoparticles Nanoprobes Organic acids Radiotherapy Tubes (components) X ray tubes X rays Contrast Enhancement Folic acids Image contrast enhancement Image contrasts Radiation dose reductions Signal intensities Specific recognition Computerized tomography gold nanoparticle contrast medium gold metal nanoparticle Article cytotoxicity Fourier transform infrared spectroscopy human human cell in vitro study KB cell line radiation dose radiation dose reduction zeta potential chemistry diagnostic imaging metabolism neoplasm pathology procedures tumor cell line Cell Line, Tumor Contrast Media Humans Neoplasms Tomography, X-Ray Computed
Subjects: WN Radiology . Diagnostic Imaging
QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 02 Jun 2020 08:12
Last Modified: 02 Jun 2020 08:12

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