Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin

Boroumand, N. and Samarghandian, S. and Hashemy, S. I. (2018) Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. Journal of HerbMed Pharmacology, 7 (4). pp. 211-219.

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Turmeric is a widely used spice derived from the rhizomes of Curcuma longa. Having been used as a dietary spice, it has drawn scientists' attention to the possible medicinal benefits of its active compounds called curcuminoids which consist of curcumin, demethoxycurcumin and bisdemethoxycurcmin. Considering wide range of pharmacological properties that curcumin offers, numerous studies have investigated its potency as a therapeutic agent in various diseases such as autoimmune, cardiovascular, neoplastic, pulmonary, neurodegenerative and metabolic diseases. With regard to its wide array of health benefits and published data on the underlying mechanisms of its action, a complex interaction between three main events including inflammation, oxidative stress, and immunity, seems to contribute to different therapeutic roles of this compound. Hence, this review discusses the current knowledge on the anti-inflammatory, antioxidant, and immunomodulatory roles of curcumin with the hope of recruiting curcumin as a therapeutic agent in future therapeutic regimen in order to enhance the efficacy of the treatment, as well as decreasing the adverse effects of synthetic chemical drugs. © 2018 by the authors.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 Correspondence Address: Hashemy, S.I.; Surgical Oncology Research Center, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Anti-inflammation Antioxidant Curcumin Immuno-modulation Oxidative stress
Subjects: QU Biochemistry
QV pharmacology
QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 06 Jun 2020 03:55
Last Modified: 06 Jun 2020 03:55

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