Neonatal hypernatremic dehydration and thrombocytopenia: Its prevalence and relationship with prognosis

Boskabadi, H. and Rakhshanizadeh, F. (2018) Neonatal hypernatremic dehydration and thrombocytopenia: Its prevalence and relationship with prognosis. Iranian Journal of Pediatrics, 28 (4).

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Background: Understanding the risk factors for neonatal hypernatremic dehydration (NHD) may help to control the problem of these infants. Objectives: In this study, the level of platelets in NHD infants and its relationship with prognosis have been evaluated. Methods: This study consisted of 390 neonates who were referred to the Neonatal Clinic, Emergency Ward and Neonatal Intensive Care Unit in Ghaem Hospital, Mashhad, Iran from 2011-2017. Demographic data, symptoms of disease, physical examination, and laboratory investigations were evaluated in these patients. At first, based on the serum sodium level, the infants were divided into two groups: isonatremia (serum sodium level < 150 mEq/L) and hypernatremia (serum sodium level ≥ 150 mEq/L). In the next stage, the infants were divided into two groups: hypernatremic dehydration with normal platelet levels (platelet ≥ 150,000 /mcl) and hypernatremic dehydration occurring with thrombocytopenia (platelet < 150,000 /mcl). In the next step, the NHD infants were followed up using the questionnaire existing in Denver Developmental Test II (DDT II) at 6, 12, 18, 24, 30 and 36 months. Results: Thrombocytopenia was observed in 41 of patients with hypernatremia and 6 of isonatremic infants (P < 0.05). Significant differences were found between the groups of normal platelet and low platelet levels in terms of age, sex, weight loss, blood glucose, sodium, blood urea nitrogen, creatinine, complications and prognosis (P < 0.05). Conclusions: Our findings showed a strong relationship between hypernatremia and thrombocytopenia in NHD infants. There were more complications and worse prognosis in patients with thrombocytopenia (P < 0.05). © 2018, Iranian Journal of Pediatrics.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Rakhshanizadeh, F.; Department of Pediatrics, Mashhad University of Medical Sciences, Emam Reza HospitalIran; email:
Uncontrolled Keywords: Creatinine Denver test 2 Neonatal hypernatremic dehydration Prognosis Thrombocytopenia Urea glucose nitrogen adult age Article body weight loss cohort analysis dehydration demography Denver Developmental Screening Test disease association female follow up gender glucose blood level human hypernatremia infant laboratory test major clinical study male newborn physical examination platelet count prevalence prognostic assessment questionnaire sodium blood level symptom urea nitrogen blood level
Subjects: WJ Urogenital System
WS Pediatrics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 26 May 2020 03:28
Last Modified: 26 May 2020 03:28

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