The neuroprotective effects of thymoquinone: A review

Farkhondeh, T. and Samarghandian, S. and Shahri, A. M. P. and Samini, F. (2018) The neuroprotective effects of thymoquinone: A review. Dose-Response, 16 (2).

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Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very useful biomedical effects such as antiinflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are not fully described. The literature search has indicated many studies pertaining to the effects of TQ in neurological problems such as epilepsy, parkinsonism, anxiety, and improvement of learning and memory, and so on. In addition, TQ protected brain cells from various injuries due to its antioxidant, anti-inflammatory, and apoptotic effects in cell line and experimental animal models. The present study has been designed to review the scientific literature about the pharmacological activities of TQ to the neurological diseases. This study purposed that although experimental studies indicated the beneficial effects of TQ against nervous system problems, better designed clinical trials in humans are needed to confirm these effects. © The Author(s) 2018.

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020 Correspondence Address: Samarghandian, S.; Department of Basic Medical Sciences, Neyshabur University of Medical SciencesIran; email:
Uncontrolled Keywords: Anti-inflammation Antioxidant Apoptosis Neurodegenerative diseases Thymoquinone 1 (5 chloro 2,4 dimethoxyphenyl) 3 (5 methyl 3 isoxazolyl)urea 4 chloro n (3 quinuclidinyl)benzamide ascorbic acid Nigella sativa extract Alzheimer disease antiinflammatory activity antioxidant activity anxiety black cumin depression dose response drug bioavailability drug clearance drug distribution drug effect drug elimination drug exposure drug half life drug mechanism drug metabolism drug structure epilepsy epileptic state experimental autoimmune encephalomyelitis human intractable epilepsy LD50 learning memory nervous system inflammation neuroprotection nonhuman Note Parkinson disease parkinsonism seizure temporal lobe epilepsy transient ischemic attack traumatic brain injury
Subjects: WL Nervous system
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 20 May 2020 07:18
Last Modified: 20 May 2020 07:18

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