Curcumin in liver diseases: A systematic review of the cellular mechanisms of oxidative stress and clinical perspective

Farzaei, M. H. and Zobeiri, M. and Parvizi, F. and El-Senduny, F. F. and Marmouzi, I. and Coy-Barrera, E. and Naseri, R. and Nabavi, S. M. and Rahimi, R. and Abdollahi, M. (2018) Curcumin in liver diseases: A systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients, 10 (7).

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Abstract

Oxidative stress has been considered a key causing factor of liver damage induced by a variety of agents, including alcohol, drugs, viral infections, environmental pollutants and dietary components, which in turn results in progression of liver injury, non-alcoholic steatohepatitis, non-alcoholic liver disease, liver fibrosis and cirrhosis. During the past 30 years and even after the major progress in the liver disease management, millions of people worldwide still suffer from an acute or chronic liver condition. Curcumin is one of the most commonly used indigenous molecules endowed by various shielding functionalities that protects the liver. The aim of the present study is to comprehensively review pharmacological effects and molecular mechanisms, as well as clinical evidence, of curcumin as a lead compound in the prevention and treatment of oxidative associated liver diseases. For this purpose, electronic databases including “Scopus,” “PubMed,” “Science Direct” and “Cochrane library” were extensively searched with the keywords “curcumin or curcuminoids” and “hepatoprotective or hepatotoxicity or liver” along with “oxidative or oxidant.” Results showed that curcumin exerts remarkable protective and therapeutic effects of oxidative associated liver diseases through various cellular and molecular mechanisms. Those mechanisms include suppressing the proinflammatory cytokines, lipid perodixation products, PI3K/Akt and hepatic stellate cells activation, as well as ameliorating cellular responses to oxidative stress such as the expression of Nrf2, SOD, CAT, GSH, GPx and GR. Taking together, curcumin itself acts as a free radical scavenger over the activity of different kinds of ROS via its phenolic, β-diketone and methoxy group. Further clinical studies are still needed in order to recognize the structure-activity relationships and molecular mechanisms of curcumin in oxidative associated liver diseases. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Item Type: Article
Additional Information: Cited By :38 Export Date: 16 February 2020 Correspondence Address: Farzaei, M.H.; Pharmaceutical Sciences Research Center, Kermanshah University of Medical SciencesIran; email: mh.farzaei@gmail.com
Uncontrolled Keywords: Curcumin Hepatotoxicity Liver diseases Oxidative stress Systematic review alanine aminotransferase aldehyde dehydrogenase alkaline phosphatase aspartate aminotransferase bilirubin carnitine palmitoyltransferase I catalase cholesterol cytochrome P450 cytokine glutathione glutathione peroxidase glutathione reductase heme oxygenase 1 high density lipoprotein cholesterol isocitrate dehydrogenase 2 low density lipoprotein low density lipoprotein cholesterol malonaldehyde messenger RNA microRNA mitogen activated protein kinase mitogen activated protein kinase kinase reactive oxygen metabolite superoxide dismutase thiobarbituric acid reactive substance transcription factor Nrf2 transforming growth factor beta triacylglycerol antioxidant alcohol liver disease AMPK signaling antioxidant activity carbon tetrachloride-induced liver injury down regulation enzyme activity gene expression human lipid peroxidation liver cirrhosis liver disease liver fibrosis liver protection liver toxicity nonalcoholic fatty liver nonhuman protein expression randomized controlled trial (topic) Review upregulation animal drug effect liver metabolism pathology pathophysiology signal transduction Animals Antioxidants Humans
Subjects: WI Digestive System
QU Biochemistry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 20 May 2020 07:24
Last Modified: 20 May 2020 07:24
URI: http://eprints.mums.ac.ir/id/eprint/17278

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