Evaluation of the effects of isotretinoin for treatment of acne on corneal sensitivity

Fouladgar, N. and Khabazkhoob, M. and Hanifnia, A. R. and Yekta, A. and Mirzajani, A. (2018) Evaluation of the effects of isotretinoin for treatment of acne on corneal sensitivity. Journal of Current Ophthalmology, 30 (4). pp. 326-329.

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Purpose: To determine the effect of isotretinoin on corneal sensitivity in acne patients. Methods: Fifty patients (13 men and 37 women) with a mean age of 23.24 ± 3.4 years were selected among patients receiving isotretinoin (1.0 mg/kg) for acne according to inclusion criteria. The Cochet-Bonnet esthesiometer was used to measure corneal sensitivity (in mm filament length) two times (the measurements were done immediately before starting the medication, then 3 months after that), including 3 measurements each time, between 11 a.m. and 1 p.m. by an experienced operator. The average of the 3 measurements in each time was recorded as the final value. One-way analysis of variance and Chi square were used for quantitative and qualitative comparison of corneal sensitivity before and after isotretinoin use, respectively. Results: The mean corneal sensitivity was 5.54 ± 0.05 before medication consumption which decreased to 5.41 ± 0.05 after isotretinoin treatment for 3 months (P < 0.005). After controlling the effect of age and sex, the decrease of corneal sensitivity was markedly significant (P = 0.003) as decreased corneal sensitivity was more pronounced at higher ages and in female gender. In non-parametric evaluation, corneal sensitivity was categorized as substantial (5.5–6 mm), intermediate (4.5–5.5 mm), and low (3.5–4.5). About 72 of the participants had substantial corneal sensitivity before drug consumption, which decreased to 60 after 3 months of treatment. Conclusions: According to the results of this study, corneal sensitivity decreases after three months of treatment with isotretinoin. This decrease is more pronounced at higher ages and in women. © 2018 Iranian Society of Ophthalmology

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Mirzajani, A.; Department of Optometry, Iran University of Medical Sciences, Madar SQR, Mirdamad Avenue, Iran; email: Mirzajani.a@iums.ac.ir
Uncontrolled Keywords: Acne Cochet-Bonnet esthesiometer Corneal sensitivity Isotretinoin adult age Article clinical article drug use female human male qualitative analysis quantitative analysis sex factor visual system parameters
Subjects: WW Ophthalmology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 20 May 2020 06:18
Last Modified: 20 May 2020 06:18
URI: http://eprints.mums.ac.ir/id/eprint/17287

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