Protective effects of n-acetyl-l-cysteine on the density of spiral ganglion cells and histological changes induced by continuous noise exposure in rats

Habybabady, R. H. and Mortazavi, S. B. and Khavanin, A. and Mirzaei, R. and Arab, M. R. and Mesbahzadeh, B. and Hoseini, M. and Mohammadi, M. (2018) Protective effects of n-acetyl-l-cysteine on the density of spiral ganglion cells and histological changes induced by continuous noise exposure in rats. Malaysian Journal of Medical Sciences, 25 (5). pp. 48-58.

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Abstract

Background: Noise exposure causes loss of cochlea hair cells, leading to permanent sensorineural hearing loss, and initiates pathological changes to the bipolar primary auditory neurons (ANs). This study focuses on the effects of N-acetyl-l-cysteine (NAC) in protecting the density of spiral ganglion cells and in histological changes induced by continuous noise exposure in rats. Methods: Twenty-four male Wistar rats were randomly allocated into four experimental groups to receive NAC, saline, noise, or both noise and NAC. Noise exposure continued for ten days. Saline and NAC were injected daily during the noise exposure, and 2 days before and after the noise exposure. Evaluation of cochlear histopathology and the density of spiral ganglion cells was performed 21 days after exposure. Results: In the animals exposed to noise, a reduction in the density of spiral ganglion cells was evident in both the basal and middle turns of the cochlea. This improved on receiving NAC treatment (P = 0.046). In the histopathology evaluation, some histological changes, such as disorganised architecture of the outer hair and supporting cells and a slightly thickened basilar membrane, were found in the basal turns in the noise group. Conclusion: NAC offered partial protection against noise exposure by improving the density of spiral ganglion cells and reducing morphological changes. © 2018, Penerbit Universiti Sains Malaysia. All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: MJMSA Correspondence Address: Mohammadi, M.; Health Promotion Research Center, Department of Biostatistics and Epidemiology, Zahedan University of Medical SciencesIran; email: memohammadi@yahoo.com
Uncontrolled Keywords: Cochlea Hearing loss Histology N-acetyl-l-cysteine Noise Spiral ganglion cells acetylcysteine animal cell animal tissue Article basilar membrane cell density cell protection cell structure cochlea tissue controlled study drug effect drug efficacy drug mechanism drug response male morphology nerve cell nonhuman rat spiral ganglion cell Wistar rat
Subjects: QS Human Anatomy
WA Public Health
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 18 May 2020 08:18
Last Modified: 18 May 2020 08:18
URI: http://eprints.mums.ac.ir/id/eprint/17306

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