Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats

Hedayati, M. and Niazmand, S. and Hosseini, M. and Baghcheghi, Y. and Beheshti, F. and Niazmand, M. J. (2018) Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats. Endocrine Regulations, 51 (4). pp. 205-212.

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Abstract

Objectives. Th e objective of this study was to evaluate the eff ect of Vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. Methods. Th e animals were divided into 4 experimental groups: Group 1 (Euthyroid) received tap water, Group 2 (Hypothyroid) received 0.05 of PTU in dissolved in their drinking water, Group 3 (PTU+Vit E) hypothyroid rats treated with Vitamin E, and Group 4 (Euthyroid+Vit E). Vitamin E was injected daily (20 mg/kg) to groups 3 and 4 via daily gavage for 6 weeks. Malondialdehyde (MDA) levels, total thiol levels, and the activities of Cu, Zn-superoxide dismutase (SOD) and catalase (CAT) were evaluated in the aortic and cardiac tissues. Results. A signifi cant decrease of thyroxine (T4) serum levels confi rmed hypothyroidism in rats, which received PTU. Th e MDA level increased and total thiol level decreased in the hypothyroid group compared to control group (p<0.001). Th e activities of SOD and CAT signifi cantly decreased in the hypothyroid rats in comparison to the control. Vitamin E treatment resulted in increased levels of total thiol, SOD, and CAT within aortic and cardiac tissues and decreased levels of MDA in comparison with the hypothyroid group (p<0.01-p<0.001). Conclusions. PTU-induced hypothyroidism resulted in oxidative stress. Chronic administration of Vitamin E to hypothyroid rats decreased the oxidative stress markers in the aortic and cardiac tissues. © 2018 De Gruyter Open Ltd. All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: EREGE Correspondence Address: Niazmand, M.J.; Department of Physiology, School of MedicineIran; email: niazmands@mums.ac.ir
Uncontrolled Keywords: Aorta Heart Hypothyroidism Oxidative stress alpha tocopherol catalase copper zinc superoxide dismutase malonaldehyde thiobarbituric acid reactive substance thiol thyroxine antioxidant superoxide dismutase animal experiment animal tissue aortic tissue Article chemiluminescence immunoassay controlled study enzymatic assay euthyroidism heart tissue homeostasis lipid peroxidation MTT assay nonhuman oxidation reduction reaction propylthiouracil-induced hypothyroidism radioimmunoassay rat spectrophotometry thyroxine blood level animal blood cardiac muscle drug effect male metabolism Wistar rat Animals Antioxidants Malondialdehyde Myocardium Oxidation-Reduction Rats Rats, Wistar Vitamin E
Subjects: WG Cardiovascular System
WK Endocrine System
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 18 May 2020 06:51
Last Modified: 18 May 2020 06:51
URI: http://eprints.mums.ac.ir/id/eprint/17319

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