Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue

Hosseini, A. and Fanoudi, S. and Mollazadeh, H. and Aghaei, A. and Boroushaki, M. (2018) Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue. Journal of Pharmacy and Bioallied Sciences, 10 (2). pp. 66-71.

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Abstract

Background: Cisplatin is used as chemotherapeutic drug in the treatment of some solid tumors. It causes different side effects such as nephrotoxicity because of increasing oxidative stress and reactive oxygen species production. This study was designed to investigate the effect of Rheum turkestanicum on cisplatin-induced nephrotoxicity in rat. Materials and Methods: Animals were randomly divided into four groups (six each). Group I received normal saline (1mL/day, intraperitoneally i.p.). Group II received a single dose of cisplatin (8mg/kg, i.p.). Groups III and IV received extract at doses of 100mg/kg and 200mg/kg, i.p., respectively, for 3 consecutive days, 1h before a single dose of cisplatin only at the first day. Blood samples were taken for measuring the level of urea and creatinine. Furthermore, 24-h urinary factors such as glucose and protein were measured. Histopathological observation was carried out on kidney sections. Statistical analysis was performed using one-way analysis of variance followed by Tukey-Kramer post hoc test for multiple comparisons. Results: Cisplatin increased the lipid peroxidation, serum creatinine, serum urea, urinary glucose, and urinary protein, whereas decreased the content of thiol in kidney. The extract reduced serum creatinine, serum urea, urinary glucose, urinary protein, lipid peroxidation, and increased thiol following cisplatin administration. Histological studies revealed lower lesions in kidney in the extract-treated groups compared to cisplatin-treated one. Conclusion: This research showed the extract has protective effect against cisplatin-induced nephrotoxicity. This observation may be related to antioxidant properties of the extract. © 2018 Journal of Pharmacy and Bioallied Sciences Published by Wolters Kluwer-Medknow.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Boroushaki, M.; Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: boroushakimt@mums.ac.ir
Uncontrolled Keywords: Cisplatin nephrotoxicity oxidative stress Rheum turkestanicum ROS antioxidant creatinine glucose plant extract protein Rheum turkestanicum extract thiol unclassified drug urea animal experiment animal model animal tissue antioxidant activity Article controlled study creatinine blood level histopathology lipid peroxidation nonhuman priority journal rat renal protection Rheum single drug dose urea blood level urine level
Subjects: WJ Urogenital System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 12 May 2020 08:37
Last Modified: 12 May 2020 08:37
URI: http://eprints.mums.ac.ir/id/eprint/17328

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