Prognostic significance of adjuvant radiation therapy in adenocarcinoma of the cecum

Hosseini, S. and Bananzadeh, A. M. and Mohammadianpanah, M. and Salek, R. and Taghizadeh-Kermani, A. (2018) Prognostic significance of adjuvant radiation therapy in adenocarcinoma of the cecum. Radiation Oncology Journal, 36 (1). pp. 45-53.

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Abstract

Purpose: Local recurrence is a common failure pattern in adenocarcinoma of the cecum. This study aimed to investigate the potential role of adjuvant radiation therapy on oncologic outcomes of patients with adenocarcinoma of the cecum. Materials and Methods: This retrospective study was carried out at three large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of 162 patients with adenocarcinoma of the cecum that were treated and followed up between 2000 and 2013. All the patients had undergone a right hemicolectomy and received chemotherapy with (n = 48) or without (n = 114) adjuvant radiation therapy. Results: The subjects were 65 females and 97 males with a median age of 56 years (range, 17 to 90 years) at diagnosis. The 5-year local control (LC), disease free survival (DFS), and overall survival (OS) rates were 72.7, 57.2, and 62.6 respectively. In a multivariate analysis, age, tumor stage, node stage, and adjuvant radiation therapy were determined to be independent prognostic factors. Age more than 55 years (hazard ratio HR = 1.0; 95% confidence interval CI, 0.06–0.32; p = 0.003), T4 stage (HR = 6.8; 95% CI, 3.07–15.36; p < 0.001), node positive disease (HR = 4.2; 95% CI, 1.94–9.13; p < 0.001), and the absence of adjuvant radiation therapy (HR = 3.0; 95% CI, 1.39–6.46; p = 0.005) had a negative influence on OS. Conclusion: Adjuvant radiation therapy significantly improves DFS and OS in patients with adenocarcinoma of the cecum. © 2018. The Korean Society for Radiation Oncology.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Mohammadianpanah, M.; Colorectal Research Center, Department of Radiation Oncology, Shiraz University of Medical SciencesIran; email: mohpanah@sums.ac.ir
Uncontrolled Keywords: Adenocarcinoma Adjuvant radiation therapy Cecum Colon Prognosis capecitabine carcinoembryonic antigen fluorouracil folinic acid oxaliplatin abdominal pain adjuvant radiotherapy adult aged Article blood cell count cancer chemotherapy cancer prognosis cancer staging cecum carcinoma colonoscopy computer assisted tomography diarrhea disease free survival female follow up gastrointestinal toxicity hemicolectomy human major clinical study male middle aged multiple cycle treatment overall survival radiation dose retrospective study surgical margin tumor invasion tumor volume
Subjects: WI Digestive System
WN Radiology . Diagnostic Imaging
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 18 May 2020 04:11
Last Modified: 18 May 2020 04:11
URI: http://eprints.mums.ac.ir/id/eprint/17332

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