Efficacy of black seed (Nigella sativa) and lemon balm (melissa officinalis) on non-alcoholic fatty liver disease: A randomized controlled clinical trial

Hosseini, S. M. R. and Razmgah, G. R. G. and Nematy, M. and Esmaily, H. and Yousefi, M. and Kamalinejad, M. and Mosavat, S. H. (2018) Efficacy of black seed (Nigella sativa) and lemon balm (melissa officinalis) on non-alcoholic fatty liver disease: A randomized controlled clinical trial. Iranian Red Crescent Medical Journal, 20 (3).

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Efficacy of black seed (Nigella sativa) and lemon balm (melissa officinalis) on non-alcoholic fatty liver disease A randomized controlled clinical trial.pdf

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Abstract

Background: There are several therapeutic strategies available from the viewpoint of Traditional Persian Medicine (TPM) to treat hepatic diseases. Objectives: This study aimed at assessing the efficacy and safety of Nigella sativa and Melissa officinalis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). Methods: From November 2014 to May 2016, in an open-label, simple-blocked, randomized controlled clinical trial, the researchers evaluated the efficacy of Nigella sativa and Melissa officinalis compared with Orlistat capsule on the grade of fatty liver and the serum levels of Aspartate Transaminase (AST) and Alanine Transaminase (ALT) in 50 patients with NAFLD in Iran. Results: Regarding within-group changes, a significant decrease was observed in the serum level of AST, ALT, body mass index, and grade of fatty liver in both groups after the intervention compared with baseline (P < 0.001). Repeated measures logistic regression analysis showed that there was a more significant reduction in the grade of fatty liver over the study period in the intervention group compared with the control group (0.58 ± 0.50 versus 1.51 ± 0.54, P < 0.001). Conclusion: Traditional Persian Medicine-based preparations of Nigella sativa and Melissa officinalis could reduce body weight and liver enzymes and improves the grade of fatty liver in Non-Alcoholic Fatty Liver Disease. © 2018, Iranian Red Crescent Medical Journal.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Razmgah, G.R.G.; Faculty of Iranian Traditional Medicine and Complementary Medicine, Mashhad University Medical of SciencesIran; email: ghayourgh1@mums.ac.ir
Uncontrolled Keywords: Disease Fatty Liver Lemon Balm Medicine Melissa officinalis Nigella sativa Non-Alcoholic Traditional alanine aminotransferase aspartate aminotransferase carbohydrate fat protein tetrahydrolipstatin adult Article black cumin body mass body weight controlled study drug efficacy echography human major clinical study nonalcoholic fatty liver outcome assessment randomized controlled trial risk assessment
Subjects: WI Digestive System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 18 May 2020 05:48
Last Modified: 18 May 2020 05:48
URI: http://eprints.mums.ac.ir/id/eprint/17336

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