Renoprotective effect of Nigella sativa against cisplatin-induced nephrotoxicity and oxidative stress in rat

Hosseinian, S. and Hadjzadeh, M. A. R. and Roshan, N. M. and Khazaei, M. and Shahraki, S. and Mohebbati, R. and Rad, A. K. (2018) Renoprotective effect of Nigella sativa against cisplatin-induced nephrotoxicity and oxidative stress in rat. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 29 (1). pp. 19-29.

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Abstract

Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) is an herbaceous plant with many pharmacologic effects. In the present study, we evaluated the protective effects of aqueous-ethanolic extract of N. sativa and Vitamin E on cisplatin-induced nephrotoxicity in rats. Eighty male rats were divided into eight groups: control, cisplatin (6 mg/kg; ip), preventive Vitamin E (100 mg/kg), preventive N. sativa (100,200 mg/kg), preventive + treatment Vitamin E, and preventive + treatment N. sativa (100, 200 mg/kg). Duration of this study was 11 days and cisplatin was injected on the 6th day of the experiment. Tissue damage in all groups that received N. sativa extract and Vitamin E showed a significant improvement compared with the cisplatin group. In addition, serum and tissue total thiol content in preventive and preventive + treatment N. sativa groups showed significant increase compared with cisplatin group. There was no significant difference in serum malondialdehyde concentration of the control rats compared with the preventive and preventive + treatment N. sativa groups. N. sativa extract and viamin E improved the pathology and oxidative stress in the rat kidney. However, more studies are needed to determine the mechanism of action of N. sativa on cisplatin-induced kidney toxicity.

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020
Uncontrolled Keywords: alpha tocopherol antioxidant biological marker cisplatin malonaldehyde plant extract thiol derivative animal black cumin blood cell protection chemistry disease model drug effect isolation and purification kidney kidney disease male metabolism oxidative stress pathology plant seed Wistar rat Animals Antioxidants Biomarkers Cytoprotection Disease Models, Animal Kidney Diseases Malondialdehyde Nigella sativa Plant Extracts Rats, Wistar Seeds Sulfhydryl Compounds Vitamin E
Subjects: WJ Urogenital System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 18 May 2020 05:53
Last Modified: 18 May 2020 05:53
URI: http://eprints.mums.ac.ir/id/eprint/17337

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