Association between interleukin 4 (IL-4) VNTR, gene polymorphism, and breast cancer susceptibility in Iranian population: Experimental and web base analysis

Ibrahimi, M. and Jamalzei, B. and Akbari, M. E. and Ibrahimi, R. and Alaei, M. and Moossavi, M. and Mohammadoo-Khorasani, M. (2018) Association between interleukin 4 (IL-4) VNTR, gene polymorphism, and breast cancer susceptibility in Iranian population: Experimental and web base analysis. Bratislava Medical Journal, 119 (10). pp. 651-654.

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Abstract

BACKGROUND: Breast cancer (BC) is one of the most common types of cancer and the second leading cause of cancer death among women. Epidemiological studies showed that BC is linked to genetic and environmental factors, and inheritance plays a key role in the pathobiology of this disease. Interleukin 4 (IL-4) is a key differentiation cytokine and is produced by Th2 and activates Th2 development. Hence the current study aimed to assess the possible association between interleukin 4 (IL-4) VNTR polymorphism, and BC susceptibility in a sample of Iranian population. MATERIAL AND METHODS: IL-4 VNTR polymorphism was evaluated in 150 women with BC and 150 agematched healthy women by polymerase chain reaction method. RESULT: Among 3 possible alleles for IL-4 gene, we only observed 2 alleles. Current fi ndings indicate that RP2/RP2 genotypes can be regarded as potent protective factors against breast cancer (OR = 0.929 95%CI, 0.929-0.995). CONCLUSION: Our result showed that the RP2/RP2 genotype of the IL-4 VNTR polymorphism could be a protective factor for BC susceptibility. © AEPress s.r.o.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Mohammadoo-Khorasani, M.; Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares UniversityIran; email: miladkh24@yahoo.com
Uncontrolled Keywords: Breast cancer IL-4 VNTR polymorphism interleukin 4 allele breast tumor case control study female genetic polymorphism genetic predisposition genetics genotype human Iran single nucleotide polymorphism variable number of tandem repeat Alleles Breast Neoplasms Case-Control Studies Genetic Predisposition to Disease Humans Interleukin-4 Minisatellite Repeats Polymorphism, Genetic Polymorphism, Single Nucleotide
Subjects: WP Gynecology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 18 May 2020 06:00
Last Modified: 18 May 2020 06:00
URI: http://eprints.mums.ac.ir/id/eprint/17338

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