Letrozole plus 2 different gonadotropins regimens for intrauterine insemination in polycystic ovary patients: A randomized clinical trial

Jafarabadi, M. N. and Vahed, S. H. M. and Afiat, M. and Ebrahimi, Z. and Shiva, Z. S. and Haghollahi, F. (2018) Letrozole plus 2 different gonadotropins regimens for intrauterine insemination in polycystic ovary patients: A randomized clinical trial. International Journal of Women's Health and Reproduction Sciences, 6 (4). pp. 420-424.

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Abstract

Objectives: The purpose of this study was to compare the effects of letrozole plus recombinant follicle stimulating hormone (R-FSH) and human menopausal gonadotropin (HMG) on ovarian stimulation in intrauterine insemination (IUI) cycle. Materials and Methods: This randomized clinical trial was conducted on 130 women with polycystic ovary syndrome (PCOS) resistant to clomiphene and letrozole who were divided into A and B groups. Both groups received 5 mg of letrozole daily from the third to seventh day of the cycle and then group A (n = 59) received 75 units of HMG intramuscularly per day and group B received 75 units of R-FSH subcutaneously per day. Follicular maturation was triggered with 250 μg of recombinant human chorionic gonadotrophin (R-hCG) and IUI was performed 36 hours later. Main results under study were the number of matured follicles, endometrial thickness on the day of hCG injection, and the rate of chemical and clinical pregnancy. Results: The 2 groups were not significantly different in demographic information. The rate of pregnancy was significantly higher in the letrozole + R-FSH group than in the letrozole+HMG group (20 and 5.8 respectively, P = 0.04). There was no significant difference between the 2 groups in the number of mature follicles (≤18 mm) and endometrial thickness at the time of hCG injection (P > 0.05). Conclusions: Letrozole plus R-FSH is a recommended regimen for ovarian stimulation in PCOS patients. © 2018 The Author (s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Afiat, M.; Women’s Health Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: AfiatM@mums.ac.ir
Uncontrolled Keywords: HMG Letrozole Ovulation induction Polycystic ovary syndrome Recombinant FSH chorionic gonadotropin clomifene human menopausal gonadotropin letrax progesterone recombinant chorionic gonadotropin recombinant follitropin adult Article controlled study drug effect endometrial thickness female gender human intrauterine insemination major clinical study ovary follicle ovary follicle maturation ovary hyperstimulation ovary polycystic disease pregnancy rate randomized controlled trial single blind procedure single drug dose
Subjects: WP Gynecology
WQ Obstetrics
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 12 May 2020 03:08
Last Modified: 12 May 2020 03:08
URI: http://eprints.mums.ac.ir/id/eprint/17341

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