Maternal and neonatal metabolic outcomes of Vitamin D supplementation in gestational diabetes mellitus: A systematic review and meta-analysis

Jahanjoo, F. and Farshbaf-Khalili, A. and Shakouri, S. K. and Dolatkhah, N. (2018) Maternal and neonatal metabolic outcomes of Vitamin D supplementation in gestational diabetes mellitus: A systematic review and meta-analysis. Annals of Nutrition and Metabolism, 73 (2). pp. 145-159.

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Maternal and neonatal metabolic outcomes of Vitamin D supplementation in gestational diabetes mellitus A systematic review and meta-analysis.pdf

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Abstract

Introduction: Many scientists have revealed the association between vitamin D deficiency and gestational diabetes mellitus (GDM). The purpose of this review was to evaluate the impact of vitamin D supplementation on maternal and neonatal health measures in GDM. Methods: A comprehensive systematic literature search in the electronic databases including Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Scopus, Web of Sciences, EMBASE, Google Scholar, Clininaltrial.gov, and ProQuest as well as SID, Magiran, Irandoc, and Iranmedex for Persian literature review carried out up to January 2018. All RCTs and quasi-experimental studies that compared vitamin D supplementation with placebo or without supplementation on GDM women were included in this review. Results: Five randomized controlled trials involving 310 women were included in the meta-analysis. There were significant differences in fasting Plasma Glucose (FPG; mean difference MD -12.54, 95% CI -15.03 to -10.05; 3 trials, 223 participants); total cholesterol (TC; MD -24.77, 95% CI -32.57 to -16.98; 3 trials, 223 participants); low-density lipoprotein (LDL) cholesterol (MD -18.92, 95% CI -24.97 to -12.88; 3 trials, 223 participants); high-density lipoprotein (HDL) cholesterol (MD, 3.87, 95% CI 1.20-6.55; 3 trials, 223 participants); high sensitivity C-reactive protein -(hs-CRP; MD -1.35, 95% CI -2.41 to -0.28; 2 trials, 126 participants); and Newborns' hyperbilirubinemia (OR 0.33, 95% CI 0.13-0.80; 2 trials, 129 participants). Conclusions: Supplementation of GDM women with vitamin D may lead to an improvement in FPG, TC, LDL, HDL, hs-CRP serum levels as well as in newborns' hyperbilirubinemia. © 2018 S. Karger AG, Basel.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 CODEN: ANUMD
Uncontrolled Keywords: Gestational diabetes mellitus Meta-analysis Metabolic outcomes Supplementation Systematic review Vitamin D C reactive protein cholesterol colecalciferol glucose high density lipoprotein cholesterol high sensitivity C reactive protein insulin low density lipoprotein cholesterol placebo unclassified drug triacylglycerol cholesterol blood level glucose blood level human hyperbilirubinemia hypoglycemia insulin blood level meta analysis pregnancy diabetes mellitus priority journal randomized controlled trial (topic) Review vitamin blood level vitamin intake vitamin supplementation blood dietary supplement female newborn pregnancy Blood Glucose C-Reactive Protein Diabetes, Gestational Dietary Supplements Humans Infant, Newborn Randomized Controlled Trials as Topic Triglycerides
Subjects: WK Endocrine System
WQ Obstetrics
QU Biochemistry
WY Nursing
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 12 May 2020 04:06
Last Modified: 12 May 2020 04:06
URI: http://eprints.mums.ac.ir/id/eprint/17347

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