Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran

Kangari, P. and Farahany, T. Z. and Golchin, A. and Ebadollahzadeh, S. and Salmaninejad, A. and Mahboob, S. A. and Nourazarian, A. (2018) Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran. Asian Pacific Journal of Cancer Prevention, 19 (12). pp. 3511-3515.

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Abstract

Background: Breast cancer is caused by breast tissue malignant cells and it has become one of the main medical concerns with a socio-economic significance especially for women. Among the multiple factors involved in the initiation, progression, and invasion of breast cancer, oxidative stress plays an important role. Antioxidant status, lipid peroxidation, and oxidative stress in newly diagnosed breast cancer patients were determined to find a defined pattern of oxidative stress in these patients. Methods: The malondialdehyde (MDA) levels (as an indicator of lipid peroxidation), glutathione peroxidase (GPX), and superoxide dismutase (SOD) activities of newly diagnosed breast cancer patients (n=38) and controls (n=38) were assessed using blood samples. Results: MDA level and SOD activity were significantly higher in the breast cancer patients compared to the healthy subjects group (p < 0.05). Compared to the healthy group, GPX activity decreased significantly in patients group (p < 0.05). Conclusions: High lipid peroxidation is an important risk factor for breast cancer and the increased levels of superoxide anion in breast cancer cells may be a reason for the induction of SOD activity. Nevertheless, oxidative stress is an important factor in development and progression of breast cancer. Further studies on it can lead to a more helpful approach to management of breast cancer. © 2018, Asian Pacific Organization for Cancer Prevention.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Golchin, A.; Department of Tissue engineering and Applied Cell Sciences, Student Research Committee, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical SciencesIran; email: Agolchin.vet10@yahoo.com
Uncontrolled Keywords: Breast cancer Glutathione peroxidase Lipid peroxidation Oxidative stress Superoxide dismutase antioxidant catalase malonaldehyde superoxide adult breast tumor case control study erythrocyte female human Iran metabolism physiology Antioxidants Breast Neoplasms Case-Control Studies Erythrocytes Humans Malondialdehyde Superoxides
Subjects: WP Gynecology
QU Biochemistry
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 11 May 2020 07:06
Last Modified: 11 May 2020 07:06
URI: http://eprints.mums.ac.ir/id/eprint/17353

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