Association of tumor necrosis factor-α -308 G/A gene polymorphism with coronary artery diseases: An evidence-based study

Kazemi, E. and Jamialahmadi, K. and Avan, A. and Mirhafez, S. R. and Mohiti, J. and Pirhoushiaran, M. and Hosseini, N. and Mohammadi, A. and Ferns, G. A. and Pasdar, A. and Ghayour-Mobarhan, M. (2018) Association of tumor necrosis factor-α -308 G/A gene polymorphism with coronary artery diseases: An evidence-based study. Journal of Clinical Laboratory Analysis, 32 (1).

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Abstract

Background: Coronary artery disease (CAD) is the leading cause of death worldwide and remains a major health problem, providing the rationale for identification of molecular markers for detection of individuals at high risk of developing CAD. Tumor necrosis factor-α (TNF-α) plays a crucial role in the pathogenesis of CAD. We have therefore explored the association of TNF-α 308 (G/A) gene polymorphism in 903 individuals with/without CAD. Methods: TNF-α 308 gene polymorphism was analyzed in 903 subjects of whom 222 were healthy controls. Among the 681 patients who were investigated angiographically, 468 had ≧50 stenosis and 213 patients had <50 stenosis. Biochemical profiles (eg, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, and CRP) were evaluated. Associations between TNF-α genotypes with biochemical and anthropometric characteristics were determined. Results: The frequencies of TNF-α-AA or AG genotypes were significantly lower in patients classified as CAD patients with ≥ or <50 obstruction in at least one coronary artery, compared to the control group. We observed that CAD patients with ≥50 stenosis and with AA genotype were associated with higher risk of CAD with OR of 3.56 (95CI: 1.02-12.41; P=.046) using multivariate analysis. Moreover, we found that TNF-α-308-AA genotype was associated with blood pressure and CRP level in CAD patients, compared to the wild type-genotype. Conclusion: Our data showed an association of TNF-α-308G/A polymorphism with CAD patients with ≥50 obstruction, supporting the need for further investigations on the role of TNF-α-308G/A polymorphism with hypertension. © 2017 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 CODEN: JCANE Correspondence Address: Pasdar, A.; Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical SciencesIran; email: PasdarA@mums.ac.ir
Uncontrolled Keywords: coronary artery disease genotype tumor necrosis factor-α C reactive protein genomic DNA glucose high density lipoprotein cholesterol low density lipoprotein cholesterol triacylglycerol tumor necrosis factor adult aged anthropometric parameters Article biochemical analysis blood pressure cholesterol blood level controlled study coronary angiography coronary artery obstruction DNA sequence female genetic association genotype phenotype correlation glucose blood level high risk population human hypertension Iranian people major clinical study male molecular pathology polymerase chain reaction protein blood level single nucleotide polymorphism triacylglycerol blood level tumor necrosis factor alpha gene wild type case control study genetics middle aged Case-Control Studies Humans Polymorphism, Single Nucleotide Tumor Necrosis Factor-alpha
Subjects: WG Cardiovascular System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 11 May 2020 08:43
Last Modified: 11 May 2020 08:43
URI: http://eprints.mums.ac.ir/id/eprint/17357

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