Assessment of tissue reaction of rat to materials used in vascular grafts

Kazemzadeh, G. H. and Jirofti, N. and Mohebbi-Kalhori, D. and Taheri, R. (2018) Assessment of tissue reaction of rat to materials used in vascular grafts. Biomedical Research (India), 29 (13). pp. 2794-2796.

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Abstract

Background: Vascular grafts are used common in surgery. Some patients have no native vessels for auto-graft so we should use vascular graft. In this study we assessed tissue reaction of rats to materials used in vascular grafts. Materials and methods: We prepared 8 types of grafts with electro-spinning method from different materials such as polycaprolactone (PCL), polyurethane (PU) and polyethylene terephthalate (PET) in sporadic and mixture patterns. After sterilisation with ethylene oxide, grafts were implanted in subcutaneous layer of 32 rats (divided into 8 groups of 4 rats). Rats assessed for local and general responses in 45 d. Histopathological responses were assessed by pathologist after 45 d. Results: There is no mortality during study. There are no local and systemic responses. Surgical site Infection not found. Tissue reactions to polyethylene terephthalate (PET) was higher than PET (Bio). Tissue reactions to polyurethane (PU) and PU (Bio) were about equal. PU had lower reactions in comparison with (PET) and polycaprolactone (PCL). PU+PET (Bio) had lower reaction in comparison with PET+PCL (Bio) Conclusions: It seems polyurethane has lesser reaction in compared with other materials in both single and mixture. © 2018, Scientific Publishers of India. All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: BIRSE Correspondence Address: Taheri, R.; Surgical Oncology Research Center, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Electro-spinning Rat Tissue reaction Vascular graft ethylene oxide polycaprolactone polyethylene terephthalate polyurethan animal experiment animal tissue Article blood vessel graft controlled study electrospinning histopathology instrument sterilization mortality rate nonhuman surgical infection
Subjects: QS Human Anatomy
WG Cardiovascular System
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 11 May 2020 08:57
Last Modified: 11 May 2020 08:57
URI: http://eprints.mums.ac.ir/id/eprint/17359

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