Bacterial Co-infections in HIV/AIDS-positive Subjects: A Systematic Review and Meta-analysis

Khademi, F. and Yousefi-Avarvand, A. and Sahebkar, A. and Ghanbari, F. and Vaez, H. (2018) Bacterial Co-infections in HIV/AIDS-positive Subjects: A Systematic Review and Meta-analysis. Folia medica, 60 (3). pp. 339-350.

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Abstract

BACKGROUND: Bacterial infections are the most common complications in people with HIV/AIDS. There has been no previous report on the prevalence of bacterial co-infections in Iranian HIV/AIDS-positive subjects. AIM: To evaluate the frequency of bacterial infections in hospitalized HIV/AIDS-infected patients in Iran. MATERIALS AND METHODS: Based on PRISMA guidelines, a computerized search in related data banks using relevant keywords was performed in both Persian and English languages for articles that were published until March 10, 2017. A total of 1118 original articles were systematically reviewed to identify eligible studies on the prevalence of bacterial co-infections in HIV/AIDS-infected patients from Iran. After screening for inclusion and exclusion criteria, we extracted data from 28 eligible articles for the meta-analysis. RESULTS: The overall bacterial infection rate among Iranian HIV/AIDS-positive individuals was estimated to be 48.6. Gastrointestinal disorders (59.5) were the most frequent bacterial infections in this group of patients followed by bacterial lymphadenopathy (38.9), TB infection (38.2), bacterial pneumonia (31.2), brucellosis (26.3), skin infections (13.3) and sexually transmitted infections (9.7). The prevalence of other bacterial infections including endocarditis, sepsis and Staphylococcus aureus (S. aureus) were 10, 9.1, and 6.9, respectively. CONCLUSION: The prevalence of a wide spectrum of bacterial co-infections, especially endemic infections, in Iranian HIV/AIDS-infected patients, is alarming and calls for urgent need to improve the currently applied diagnostic and preventive methods. In addition, timely treatment of these infections is pivotal to decrease the morbidity and mortality rates in HIV/AIDS-infected patients.

Item Type: Article
Additional Information: Export Date: 16 February 2020
Uncontrolled Keywords: bacterial co-infection HIV/AIDS Iran acquired immune deficiency syndrome bacterial endocarditis bacterial infection bacterial pneumonia bacterial skin disease brucellosis Escherichia coli infection gastroenteritis Helicobacter infection hospitalization human Human immunodeficiency virus infection meta analysis mixed infection prevalence sepsis sexually transmitted disease Staphylococcus infection tuberculosis Acquired Immunodeficiency Syndrome Bacterial Infections Coinfection Endocarditis, Bacterial Escherichia coli Infections Helicobacter Infections HIV Infections Humans Pneumonia, Bacterial Sexually Transmitted Diseases, Bacterial Skin Diseases, Bacterial Staphylococcal Infections
Subjects: WC Communicable Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 11 May 2020 04:06
Last Modified: 11 May 2020 04:06
URI: http://eprints.mums.ac.ir/id/eprint/17365

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