Immunotherapy in allergic rhinitis: It’s effect on the immune system and clinical symptoms

Kouzegaran, S. and Zamani, M. A. and Faridhosseini, R. and Rafatpanah, H. and Rezaee, A. and Yousefzadeh, H. and Movahed, R. and Azad, F. J. and Tehrani, H. (2018) Immunotherapy in allergic rhinitis: It’s effect on the immune system and clinical symptoms. Open Access Macedonian Journal of Medical Sciences, 6 (7). pp. 1248-1252.

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Abstract

BACKGROUND: Allergic rhinitis is one of the most common allergic diseases and characterised by sneezing, rhinorrhea, nasal congestion and nasopharyngeal itching. Subcutaneous immunotherapy (SCIT) for specific allergens is an effective treatment and induces the inhibitory effect of T regulatory lymphocytes and decreases clinical symptoms in allergic rhinitis. AIM: In this study effect of subcutaneous immunotherapy with specific allergens on clinical symptoms and T regulatory and T Helper cells cytokines, in patients with allergic rhinitis are evaluated. METHODS: In this study, 30 patients with moderate to severe allergic rhinitis according to clinical criteria and positive skin prick test for aeroallergens were selected and treated by SCIT. Clinical symptoms and T cells cytokines IL4, IL17, IFN gamma, TGF beta, GITR, FOXP3 and IL-10 (by RT-PCR) were evaluated before and one year after initiation of treatment. RESULTS: Thirty (30) patients with allergic rhinitis at age range 15-45 years old were treated by SCIT, and 23 (14 female, 9 male) patients continued the study, and 7 patients did not continue treatment. After immunotherapy, clinical symptoms decreased significantly. The specific cytokines TGF beta and IL10 levels increased and changes were statistically significant. (Respectively P = 0.013 and P = 0.05) The IL17 level was also increased, but not statistically significant. (P = 0.8) IFN gamma, IL4, GITR, FOXP3, all decreased, but the changes were not statistically significant (P > 0.05). CONCLUSION: Subcutaneous Immunotherapy for specific allergens decreases clinical symptoms in patients with allergic rhinitis and induces tolerance in T lymphocytes, especially by increasing T regulatory cells cytokines, TGF beta and IL10. © 2018 Samaneh Kouzegaran, Mohammad Ali Zamani, Reza Faridhosseini, Houshang Rafatpanah, Abdolrahim Rezaee, Hadis Yousefzadeh, Rahman Movahed, Farahzad Jabbari Azad, Hooman Tehrani.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Tehrani, H.; Allergy Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical SciencesIran; email: TehraniH911@mums.ac.ir
Uncontrolled Keywords: Allergic rhinitis Cytokine Subcutaneous immunotherapy allergen allergovit gamma interferon glucocorticoid induced tumor necrosis factor receptor immunomodulating agent interleukin 10 interleukin 17 interleukin 4 transcription factor FOXP3 transforming growth factor beta unclassified drug adolescent adult Article clinical article controlled study disease severity female helper cell human immune response immunological tolerance immunology male physical examination plant product prick test regulatory T lymphocyte reverse transcription polymerase chain reaction structured questionnaire symptom treatment response
Subjects: WF Respiratory System
QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 11 May 2020 06:07
Last Modified: 11 May 2020 06:07
URI: http://eprints.mums.ac.ir/id/eprint/17375

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