Comparison of vitamin D serum values between rheumatoid arthritis and lupus populations: An observational study

Maryam, S. and Atabati, E. and Yalda, R. (2018) Comparison of vitamin D serum values between rheumatoid arthritis and lupus populations: An observational study. Open Rheumatology Journal, 12. pp. 65-69.

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Abstract

Background: In recent years, the role of Vitamin D (VitD), as an immunomedulator in autoimmune diseases, has been evaluated in basic science and practice. There is a considerable volume of data on the effect of VitD position in lupus and rheumatoid arthritis exacerbation. Objective: This study aims to compare VitD serum values in lupus (SLE) and Rheumatoid Arthritis (RA) in the geographical region of northeastern Iran. Methods: Lupus and RA Patients were selected with various disease activity levels. All the patients received an equal amount of VitD supplementation and were selected by the same inclusion and exclusion criteria. VitD serum values were measured by a commercial ELISA kit. Data were analyzed in SPSS-15. Results: A total of 148 SLE and 156 RA patients were studied. VitD serum levels were 66.54±41.2 nmol/l in the SLE group and 83.74±46.45 nmol/l in the RA group. Statistical analysis showed that VitD serum levels were lower in lupus patients than RA ones (p=0.006). Conclusion: VitD serum values were lower in lupus patients than RA ones. Since VitD deficiency is very common in Iran, physiologic doses of VitD supplementation in patients lead to higher serum levels of VitD. Lower VitD values in lupus patients compared with RA ones may stem from intestinal malabsorption, higher doses of corticosteroid therapy, renal involvement and proteinuria, different polymorphisms of VitD receptors, and more sun protection strategies in lupus patients. © 2018 Maryam et al.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Atabati, E.; Rheumatic Diseases Research Center, Mashhad University of Medical SciencesIran; email: elham1405@yahoo.com
Uncontrolled Keywords: 25(OH) D Lupus RA Rheumatoid Arthritis SLE Vitamin D VitD calcium hydroxychloroquine sunscreen vitamin D receptor adult Article controlled study corticosteroid therapy disease activity disease duration DNA polymorphism enzyme linked immunosorbent assay female geographic distribution human Iran major clinical study malabsorption male observational study priority journal proteinuria retrospective study risk factor systemic lupus erythematosus vitamin blood level vitamin supplementation
Subjects: WE Musculoskeletal system
QU Biochemistry
QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 06:02
Last Modified: 09 May 2020 06:02
URI: http://eprints.mums.ac.ir/id/eprint/17388

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