Effect of magnesium supplements on serum C-reactive protein: A systematic review and meta-analysis

Mazidi, M. and Rezaie, P. and Banach, M. and on behalf of, Lipid and Blood Pressure Meta-analysis Collaboration, Group (2018) Effect of magnesium supplements on serum C-reactive protein: A systematic review and meta-analysis. Archives of Medical Science, 14 (4). pp. 707-716.

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Abstract

Introduction: The aim of the study was to undertake a systematic review and meta-analysis of prospective studies to determine the effect of magnesium (Mg) supplementation on C-reactive protein (CRP). Design: Systematic review and meta-analysis of randomised controlled trials (RCTs). Material and methods: Data sources: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until December 2016). Eligibility criteria: Randomized controlled trials evaluating the impact of Mg supplementation on CRP. We used random effects models meta-analysis for quantitative data synthesis. For sensitivity analysis was used the leave-one-out method. Heterogeneity was quantitatively assessed using the I2 index. Main outcome: Level of CRP after Mg supplementation. Results: From a total of 96 entries identified via searches, eight studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following Mg supplementation (weighted mean difference (WMD) –1.33 mg/l; 95 CI: –2.63 to –0.02, heterogeneity p < 0.123; I2 = 29.1). The WMD for interleukin 6 was –0.16 pg/dl (95 CI: –3.52 to 3.26, heterogeneity p = 0.802; I2 = 2.3), and 0.61 mg/dl (95 CI: –2.72 to 1.48, p = 0.182, heterogeneity p = 0.742; I2 = 6.1) for fasting blood glucose. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of Mg supplementation (slope: –0.004; 95 CI: –0.03, 0.02; p = 0.720) or duration of follow-up (slope: –0.06; 95 CI: –0.37, 0.24; p = 0.681). Conclusions: This meta-analysis suggests that Mg supplementation significantly reduces serum CRP level. RCTs with a larger sample size and a longer follow-up period should be considered for future investigations to give an unequivocal answer. Copyright © 2018 Termedia & Banach.

Item Type: Article
Additional Information: (LBPMC) Cited By :4 Export Date: 16 February 2020 Correspondence Address: Mazidi, M.; Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of SciencesChina; email: moshen@genetics.ac.cn
Uncontrolled Keywords: C-reactive protein Magnesium Meta-analysis C reactive protein interleukin 6 tumor necrosis factor Article body mass diastolic blood pressure dose response follow up glucose blood level human meta analysis mineral supplementation protein blood level quantitative analysis randomized controlled trial (topic) sensitivity analysis systematic review systolic blood pressure
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 07:09
Last Modified: 09 May 2020 07:09
URI: http://eprints.mums.ac.ir/id/eprint/17393

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