Data on environmentally relevant level of aflatoxin B1-induced human dendritic cells’ functional alteration

Mehrzad, J. and Bahari, A. and Bassami, M. R. and Mahmoudi, M. and Dehghani, H. (2018) Data on environmentally relevant level of aflatoxin B1-induced human dendritic cells’ functional alteration. Data in Brief, 18. pp. 1576-1580.

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Abstract

We assessed the effects of naturally occurring levels of AFB1 on the expression of key immune molecules and function of human monocyte-derived dendritic cells (MDDCs) by cell culture, RT-qPCR, and flow cytometry. Data here revealed that an environmentally relevant level of AFB1 led to remarkably weakened key functional capacity of DCs, up-regulation of key transcripts and DCs apoptosis, down-regulation of key phagocytic element, CD64, and creation of pseudolicensing direction of DCs. Flow cytometry data confirmed a damage towards DCs, i.e., increased apoptosis. The detailed data and their mechanistic effects and the outcome are available in this research article (Mehrzad et al., 2018) 1. The impaired phagocytosis capacity with triggered pseudolicensing direction of MDDCs caused by AFB1 and dysregulation of the key functional genes could provide a mechanistic explanation for the observed in vivo immunotoxicity associated with this mycotoxin. © 2018 The Authors

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Mehrzad, J.; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of TehranIran; email: mehrzad@ut.ac.ir
Uncontrolled Keywords: AFB1 AFB1-detoxifying genes Apoptosis Dendritic cells Flow cytometry Functional genes Immunnoderegulation Phagocytosis RT-qPCR
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 08:25
Last Modified: 09 May 2020 08:25
URI: http://eprints.mums.ac.ir/id/eprint/17397

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