Cell Cycle Regulation of Stem Cells by MicroRNAs

Mens, M. M. J. and Ghanbari, M. (2018) Cell Cycle Regulation of Stem Cells by MicroRNAs. Stem Cell Reviews and Reports, 14 (3). pp. 309-322.

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Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the regulation of gene expression. They are involved in the fine-tuning of fundamental biological processes such as proliferation, differentiation, survival and apoptosis in many cell types. Emerging evidence suggests that miRNAs regulate critical pathways involved in stem cell function. Several miRNAs have been suggested to target transcripts that directly or indirectly coordinate the cell cycle progression of stem cells. Moreover, previous studies have shown that altered expression levels of miRNAs can contribute to pathological conditions, such as cancer, due to the loss of cell cycle regulation. However, the precise mechanism underlying miRNA-mediated regulation of cell cycle in stem cells is still incompletely understood. In this review, we discuss current knowledge of miRNAs regulatory role in cell cycle progression of stem cells. We describe how specific miRNAs may control cell cycle associated molecules and checkpoints in embryonic, somatic and cancer stem cells. We further outline how these miRNAs could be regulated to influence cell cycle progression in stem cells as a potential clinical application. © 2018, The Author(s).

Item Type: Article
Additional Information: Cited By :29 Export Date: 16 February 2020 Correspondence Address: Ghanbari, M.; Department of Epidemiology, Erasmus University Medical Center, P.O. Box 2040, Netherlands; email: m.ghanbari@erasmusmc.nl
Uncontrolled Keywords: Cancer stem cell Cell cycle ESC MicroRNA Somatic stem cell Stem cells microRNA 125b microRNA 128 microRNA 137 microRNA 150 microRNA 15a microRNA 16 microRNA 17 92 microRNA 200 microRNA 203 microRNA 21 microRNA 221 microRNA 222 microRNA 23b microRNA 26a microRNA 31 microRNA 34 microRNA 365 microRNA 494 3p microRNA 605 microRNA 93 unclassified drug apoptosis biogenesis cell cycle progression cell cycle regulation cell differentiation cell function cell maturation cell proliferation cell survival DNA replication gene expression genetic transcription human human cell human embryonic stem cell priority journal protein expression Review somatic cell stem cell adult stem cell animal cytology genetics metabolism physiology Adult Stem Cells Animals Humans MicroRNAs Neoplastic Stem Cells
Subjects: QU Biochemistry
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 08:35
Last Modified: 09 May 2020 08:35
URI: http://eprints.mums.ac.ir/id/eprint/17398

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