Biomedical applications of carbon nanomaterials: Drug and gene delivery potentials

Mohajeri, M. and Behnam, B. and Sahebkar, A. (2018) Biomedical applications of carbon nanomaterials: Drug and gene delivery potentials. Journal of Cellular Physiology, 234 (1). pp. 298-319.

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Abstract

One of the major components in the development of nanomedicines is the choice of the right biomaterial, which notably determines the subsequent biological responses. The popularity of carbon nanomaterials (CNMs) has been on the rise due to their numerous applications in the fields of drug delivery, bioimaging, tissue engineering, and biosensing. Owing to their considerably high surface area, multifunctional surface chemistry, and excellent optical activity, novel functionalized CNMs possess efficient drug-loading capacity, biocompatibility, and lack of immunogenicity. Over the past few decades, several advances have been made on the functionalization of CNMs to minimize their health concerns and enhance their biosafety. Recent evidence has also implied that CNMs can be functionalized with bioactive peptides, proteins, nucleic acids, and drugs to achieve composites with remarkably low toxicity and high pharmaceutical efficiency. This review focuses on the three main classes of CNMs, including fullerenes, graphenes, and carbon nanotubes, and their recent biomedical applications. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: Cited By :19 Export Date: 16 February 2020 CODEN: JCLLA Correspondence Address: Sahebkar, A.; Neurogenic Inflammation Research Center, Mashhad University of Medical SciencesIran; email: sahebkara@mums.ac.ir
Uncontrolled Keywords: biomedicine carbon nanotubes drug delivery fullerene gene delivery graphene antineoplastic agent biomaterial carbon nanoparticle carbon nanotube carmustine DNA double walled nanotube doxorubicin fullerene derivative gold nanoparticle locked nucleic acid lomustine microRNA nanocarrier nanomaterial nucleic acid paclitaxel peptide procarbazine protein RNA single walled nanotube small interfering RNA temozolomide biocompatibility biomedical engineering cancer therapy diagnostic value drug delivery system human immunogenicity molecular imaging nonhuman nonviral gene delivery system optical rotation priority journal Review surface area tissue engineering chemistry gene therapy gene transfer genetic procedures nanomedicine Biosensing Techniques Drug Delivery Systems Gene Transfer Techniques Genetic Therapy Humans Nanostructures Nanotubes, Carbon
Subjects: QU Biochemistry
QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 03:56
Last Modified: 09 May 2020 03:56
URI: http://eprints.mums.ac.ir/id/eprint/17403

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