Evaluation of serum cathepsin D concentrations in coronary artery disease

Mohammadpour, A. H. and Salehinejad, Z. and Elyasi, S. and Mouhebati, M. and Mirhafez, S. R. and Samadi, S. and Ghayour-Mobarhan, M. and Ferns, G. and Sahebkar, A. (2018) Evaluation of serum cathepsin D concentrations in coronary artery disease. Indian Heart Journal, 70 (4). pp. 471-475.

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Abstract

Background: Coronary artery disease (CAD) cannot be sufficiently explained by the presence of traditional risk factors. Cathepsin D has been proposed to serve as a surrogate marker of atherosclerosis but its alterations in CAD patients have not been studied. Objective: To evaluate serum cathepsin D concentrations in relation to the presence and severity of CAD. Materials and methods: A total of 104 subjects were recruited; 71 patients with suspected CAD and 33 healthy subjects. Thirty-four patients had >50 coronary stenosis of at least one artery (CAD+); the remaining 37 patients had <50 stenosis (CAD−) based on angiography. CAD+ patients were sub-divided into three sub-groups with single (SVD; n = 15), double (2VD; n = 9), and triple vessel (3VD; n = 10) disease. Serum soluble cathepsin D concentrations were determined using an enzyme-linked immunosorbent assay (ELISA). Results: Serum cathepsin D concentrations were significantly higher in the CAD+ compared with healthy control (p = 0.016) but not CAD− group (p = 0.098). Within the CAD+ group, patients with 3VD had significantly higher serum cathepsin D concentrations compared with the SVD group (p = 0.025), and also compared with the CAD− (p = 0.011) and SVD (p = 0.001) groups. No significant associations were found between serum cathepsin D concentrations and potential confounders including age, sex, blood pressure, smoking history and dyslipidemia. Conclusion: Serum cathepsin D concentrations may be associated with the presence of CAD. © 2018 Cardiological Society of India

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: IHEJA Correspondence Address: Ghayour-Mobarhan, M.; Metabolic Syndrome Research Center, Mashhad University of Medical SciencesIran; email: GhayourM@mums.ac.ir
Uncontrolled Keywords: Angiography Atherosclerosis Cathepsin D Coronary artery disease biological marker adult Article blood pressure measurement comparative study controlled study coronary artery obstruction disease association disease classification disease severity dyslipidemia enzyme linked immunosorbent assay female groups by age human major clinical study male middle aged protein blood level sex smoking blood coronary angiography prognosis retrospective study Biomarkers Enzyme-Linked Immunosorbent Assay Humans Retrospective Studies
Subjects: WG Cardiovascular System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 05:07
Last Modified: 09 May 2020 05:07
URI: http://eprints.mums.ac.ir/id/eprint/17409

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