Effects of zataria multiflora extract and carvacrol on doxorubicin-induced oxidative stress in rat brain

Mohebbati, R. and Jalili-Nik, M. and Paseban, M. and Shafei, M. N. and Rad, A. K. (2018) Effects of zataria multiflora extract and carvacrol on doxorubicin-induced oxidative stress in rat brain. Pharmaceutical Sciences, 24 (3). pp. 187-192.

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Abstract

Background: Due to the antioxidant effects of Zataria multiflora (ZM) and Carvacrol (CAR) in various problems and the prominent role of the ROS in neurotoxicity induced by Doxorubicin (DOX), this study was designed to investigate the effects of ZM hydroalcoholic extract and CAR on DOX-induced oxidative stress in rat brain Methods: 24 male rats were randomly divided into four groups including: 1)Control ,2)Doxorubicin (DOX) that received DOX via a tail vein on the first day of the study, 3,4) ZM+DOX and CAR+DOX which received ZM and CAR by gavage for 28 consecutive days. Brain tissue removed for redox markers evaluation. Results: MDA level in the DOX group was significantly increased compared to control group while in treated groups did not show any significant changes in comparison with the DOX group. Also, Thiol content in DOX group showed significant reduction compared to control group. Thiol contents in treated groups showed no significant difference compared to DOX group. Catalase (CAT) activity, an antioxidant enzyme, in the DOX group were significantly decreased compared to control group and increased in treated rats in comparison with the DOX group. Activity of Superoxide dismutase (SOD), an antioxidant enzyme, in the DOX group was significantly reduced compared to control group and increased in treated rats in comparison with the DOX group. Conclusion: The present study showed that ZM hydroalcoholic extract and CAR could inhibit DOX induced oxidative stress of the brain mainly with effect on the enzymatic antioxidant defense system. © 2018 The Authors.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Rad, A.K.; Neurogenic Inflammation Research Center, Mashhad University of Medical SciencesIran; email: khajavirada@mums.ac.ir
Uncontrolled Keywords: Brain Carvacrol Doxorubicin Oxidative stress Zataria multiflora alcohol catalase malonaldehyde plant extract superoxide dismutase thiol derivative unclassified drug water Zataria multiflora extract animal cell animal experiment animal model animal tissue antiinflammatory activity antioxidant activity Article body weight brain tissue controlled study drug effect enzyme activity intermethod comparison male nonhuman rat
Subjects: WL Nervous system
WM Psychiatry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 05:23
Last Modified: 09 May 2020 05:23
URI: http://eprints.mums.ac.ir/id/eprint/17412

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