Effects of standardized Zataria multiflora extract and its major ingredient, Carvacrol, on Adriamycin-induced hepatotoxicity in rat

Mohebbati, R. and Paseban, M. and Soukhtanloo, M. and Jalili-Nik, M. and Shafei, M. N. and Yazdi, A. J. and Rad, A. K. (2018) Effects of standardized Zataria multiflora extract and its major ingredient, Carvacrol, on Adriamycin-induced hepatotoxicity in rat. Biomedical Journal, 41 (6). pp. 340-347.

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Abstract

Background: Due to antioxidant effects of Zataria multiflora (ZM) and Carvacrol (CAR) in many cases and the prominent role of reactive oxygen species (ROS) in hepatotoxicity induced by Adriamycin (ADR), the aim of this study is to investigate the effects of ZM and CAR on ADR-induced hepatotoxicity. Methods: Twenty four male Wistar rats were randomly divided into four groups including: 1)Control, 2)Adriamycin (ADR), 3,4) ZM + ADR and CAR + ADR that received ZM and CAR for 28 consecutive days. Blood samples were collected on the days 0, 14 and 28 to determine the alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Also, the hepatic redox markers were evaluated. Results: ADR significantly increased ALP, ALT and AST in comparison with the control (p < 0.05 - p < 0.001). In CAR + ADR group, the serum ALP, ALT and AST were significantly reduced compared to those of the ADR group (p < 0.01 to p < 0.001). Also, in ZM + ADR group, serum ALP and ALT compared to ADR was significantly reduced (p < 0.001). MDA level in the ADR group significantly increased compared to control (p < 0.01). The MDA level in ZM + ADR (p < 0.05) and CAR + ADR (p < 0.01) groups were significantly reduced compared to that of ADR. Thiol levels in ZM + ADR group significantly increased compared to the ADR group (p < 0.05). The activities of CAT in the ADR group was significantly reduced compared to control (p < 0.05) and increased in treatment groups in comparison with the ADR (p < 0.01). Conclusion: Long-term administration of ZM extract and CAR could reduce the oxidative damage in the rat liver induced by ADR through the strengthening of the antioxidant system. © 2018 Chang Gung University

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Rad, A.K.; Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Azadi Square, Iran; email: khajavirada@mums.ac.ir
Uncontrolled Keywords: Adriamycin Carvacrol Hepatotoxicity Zataria multiflora alanine aminotransferase alkaline phosphatase antioxidant aspartate aminotransferase catalase doxorubicin malonaldehyde plant extract thiol unclassified drug Zataria multiflora extract terpene aerial plant part alanine aminotransferase blood level alkaline phosphatase blood level animal experiment animal model animal tissue antioxidant activity Article aspartate aminotransferase blood level blood sampling controlled study drug mechanism enzyme activity male nonhuman oxidative stress rat redox stress toxic hepatitis Wistar rat animal chemistry disease model drug effect Lamiaceae liver Animals Antioxidants Chemical and Drug Induced Liver Injury Disease Models, Animal Monoterpenes Plant Extracts Rats, Wistar
Subjects: WI Digestive System
QU Biochemistry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 05:31
Last Modified: 09 May 2020 05:31
URI: http://eprints.mums.ac.ir/id/eprint/17413

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