The protective role of curcumin in myocardial ischemia–reperfusion injury

Mokhtari-Zaer, A. and Marefati, N. and Atkin, S. L. and Butler, A. E. and Sahebkar, A. (2018) The protective role of curcumin in myocardial ischemia–reperfusion injury. Journal of Cellular Physiology, 234 (1). pp. 214-222.

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Abstract

Coronary artery disease (CAD) is a well-known pathological condition that is characterized by high morbidity and mortality. The main pathological manifestation of CAD is myocardial injury due to ischemia–reperfusion (I–R). Currently, no efficacious treatment of protecting the heart against myocardial I–R exists. Hence, it is necessary to discover or develop novel strategies to prevent myocardial-reperfusion injury to improve clinical outcomes in patients with CAD. A large body of experimental evidence supports cardioprotective properties of curcumin and the ability of this phytochemical to modify some cardiovascular risk factors. However, the detailed effects of curcumin in myocardial I–R injury are still unclear and there is a lack of evidence concerning which curcumin regimen may be ideal for myocardial I–R injury. This paper presents a brief review of the pathophysiology of myocardial I–R injury and the mechanisms of action of curcumin in reducing myocardial I–R injury. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 CODEN: JCLLA Correspondence Address: Sahebkar, A.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical SciencesIran; email: sahebkara@mums.ac.ir
Uncontrolled Keywords: coronary artery disease curcumin herbal medicine myocardial ischemia–reperfusion injury cardiovascular agent protective agent apoptosis autophagy drug mechanism heart protection human inflammation myocardial ischemia reperfusion injury nonhuman oxidative stress priority journal Review cardiac muscle drug effect heart heart infarction metabolism pathology pathophysiology reperfusion injury Humans Myocardial Infarction Myocardial Reperfusion Injury Myocardium Protective Agents
Subjects: WG Cardiovascular System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 03:47
Last Modified: 09 May 2020 03:47
URI: http://eprints.mums.ac.ir/id/eprint/17417

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