MicroRNAs: New Therapeutic Targets for Familial Hypercholesterolemia?

Momtazi, A. A. and Banach, M. and Pirro, M. and Stein, E. A. and Sahebkar, A. (2018) MicroRNAs: New Therapeutic Targets for Familial Hypercholesterolemia? Clinical Reviews in Allergy and Immunology, 54 (2). pp. 224-233.

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Abstract

Familial hypercholesterolemia (FH) is the most common inherited form of dyslipidemia and a major cause of premature cardiovascular disease. Management of FH mainly relies on the efficiency of treatments that reduce plasma low-density lipoprotein (LDL) cholesterol (LDL-C) concentrations. MicroRNAs (miRs) have been suggested as emerging regulators of plasma LDL-C concentrations. Notably, there is evidence showing that miRs can regulate the post-transcriptional expression of genes involved in the pathogenesis of FH, including LDLR, APOB, PCSK9, and LDLRAP1. In addition, many miRs are located in genomic loci associated with abnormal levels of circulating lipids and lipoproteins in human plasma. The strong regulatory effects of miRs on the expression of FH-associated genes support of the notion that manipulation of miRs might serve as a potential novel therapeutic approach. The present review describes miRs-targeting FH-associated genes that could be used as potential therapeutic targets in patients with FH or other severe dyslipidemias. © 2017, The Author(s).

Item Type: Article
Additional Information: Cited By :16 Export Date: 16 February 2020 CODEN: CRVAD Correspondence Address: Banach, M.; Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz (MUL), Zeromskiego 113, Poland; email: maciejbanach77@gmail.com
Uncontrolled Keywords: Apolipoprotein B LDL receptor LDLRAP1 Low-density lipoprotein cholesterol microRNA PCSK9 adaptor protein antagomir bile acid sequestrant cholesterol ezetimibe hydroxymethylglutaryl coenzyme A reductase inhibitor inclisiran lipid lipoprotein low density lipoprotein cholesterol low density lipoprotein receptor low density lipoprotein receptor adaptor protein 1 placebo proprotein convertase 9 small interfering RNA unclassified drug LDLR protein, human LDLRAP1 protein, human PCSK9 protein, human signal transducing adaptor protein APOB gene cholesterol blood level disease severity drug targeting dyslipidemia familial hypercholesterolemia gene gene expression regulation gene location gene locus genetic manipulation human LDLR gene LDLRAP1 gene nonhuman pathogenesis PCSK9 gene Review RNA interference transcription regulation unspecified side effect animal cardiovascular disease genetics lipid metabolism metabolism molecularly targeted therapy Adaptor Proteins, Signal Transducing Animals Apolipoproteins B Cardiovascular Diseases Dyslipidemias Humans Hyperlipoproteinemia Type II MicroRNAs Molecular Targeted Therapy Receptors, LDL
Subjects: WG Cardiovascular System
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 08 May 2020 15:54
Last Modified: 08 May 2020 15:54
URI: http://eprints.mums.ac.ir/id/eprint/17420

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