Role of the NLRP3 inflammasome in cancer

Moossavi, M. and Parsamanesh, N. and Bahrami, A. and Atkin, S. L. and Sahebkar, A. (2018) Role of the NLRP3 inflammasome in cancer. Molecular Cancer, 17 (1).

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Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy. © 2018 The Author(s).

Item Type: Article
Additional Information: Cited By :32 Export Date: 16 February 2020 CODEN: MCOAC Correspondence Address: Atkin, S.L.; Weill Cornell Medicine Qatar, PO Box 24144, Qatar; email:
Uncontrolled Keywords: Apoptosis-associated speck-like protein Caspase-1 Interleukin-1β Nod-like receptor protein 3 cryopyrin inflammasome pattern recognition receptor inhibitor of apoptosis protein interleukin 1beta breast cancer central nervous system tumor colon carcinogenesis colon epithelium colorectal cancer head and neck squamous cell carcinoma homeostasis human liver cell carcinoma lung cancer malignant neoplasm NLRP3 gene nonhuman oligomerization oncogene prostate cancer protein function protein structure Review skin cancer stomach cancer tumor promotion uterine cervix cancer animal apoptosis biological model chemistry metabolism neoplasm pathology protein multimerization structure activity relation Animals Humans Inflammasomes Inhibitor of Apoptosis Proteins Interleukin-1beta Models, Biological Neoplasms NLR Family, Pyrin Domain-Containing 3 Protein Receptors, Pattern Recognition Structure-Activity Relationship
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 08 May 2020 16:04
Last Modified: 08 May 2020 16:04

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