Comparative study of superparamagnetic iron oxide/doxorubicin co-loaded poly (lactic-co-glycolic acid) nanospheres prepared by different emulsion solvent evaporation methods

Mosafer, J. and Teymouri, M. (2018) Comparative study of superparamagnetic iron oxide/doxorubicin co-loaded poly (lactic-co-glycolic acid) nanospheres prepared by different emulsion solvent evaporation methods. Artificial Cells, Nanomedicine and Biotechnology, 46 (6). pp. 1146-1155.

[img] Text
Comparative study of superparamagnetic iron oxidedoxorubicin co-loaded poly (lactic-co-glycolic acid) nanospheres prepared by different emulsion solvent evaporation methods.pdf

Download (3MB)

Abstract

Poly (lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer for preparation of polymeric biodegradable carriers that shows attractive features and offers possibilities to tune the physicochemical characteristics, drug release properties and biological behaviour of the PLGA-based nanospheres. Double emulsion solvent evaporation methods fail when it comes to encapsulation of highly hydrophilic drugs such as doxorubicin (Dox). The reason for this defect is due to the rapid drug diffusion into the external aqueous phase before solidification of the PLGA nanospheres. In this study, we present a comprehensive comparison between the four different fabrication methods of PLGA nanospheres with a focus on double emulsion solvent evaporation-based methodologies to achieve the effective method for co-encapsulation of superparamagnetic iron oxide nanoparticles (SPIONs) and Dox into the PLGA polymer in terms of the size of nanoparticles, particle size distribution and drug loading. Therefore, the optimized ratio of the different phases and other process parameters of these methods is discussed. In conclusion, the prepared SPIO/Dox-PLGA nanospheres (NPs) via a modified double emulsion solvent evaporation method were found to be a promising delivery system in terms of particle size distribution, drug loading, release profile as well as magnetic properties for tumour therapeutic and diagnostic purposes. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Mosafer, J.; University of Medical Science, P.O. Box 9516915169, Iran; email: Mosaferj901@mums.ac.ir
Uncontrolled Keywords: double emulsion doxorubicin Drug delivery magnetic PLGA nanosphere SPIONs Biodegradable polymers Diagnosis Emulsification Evaporation Iron oxides Light transmission Nanoparticles Nanospheres Particle size Particle size analysis Size distribution Solvents Superparamagnetism Targeted drug delivery Double emulsion-solvent evaporation Double emulsions Emulsion-solvent evaporation method Physicochemical characteristics Superparamagnetic iron oxide nanoparticles Controlled drug delivery nanocarrier polyglactin polymer solvent superparamagnetic iron oxide nanoparticle drug carrier lactic acid magnetite nanoparticle polyglycolic acid polylactic acid-polyglycolic acid copolymer Article controlled study dispersity double emulsion solvent evaporation drug delivery system drug formulation drug release emulsion hydrophilicity nanoencapsulation nanofabrication phase transition physical chemistry polymerization chemical model chemical structure chemistry comparative study procedures Drug Carriers Drug Delivery Systems Drug Liberation Emulsions Magnetite Nanoparticles Models, Chemical Molecular Structure
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 08 May 2020 16:29
Last Modified: 08 May 2020 16:29
URI: http://eprints.mums.ac.ir/id/eprint/17428

Actions (login required)

View Item View Item