New natural marine antacid drug from cuttlebone

Mostoufi, A. and Bavarsad, N. and Aryanfar, S. and Akhgari, A. (2018) New natural marine antacid drug from cuttlebone. Pharmaceutical Sciences, 24 (3). pp. 227-234.

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Background: Antacids are the most commonly used medications for fast symptomatic relief of gastric disorders. Because of adverse effects, low efficiency and the high cost of some chemical antacids, identifying a natural medicine with high efficiency and low cost seems useful. Therefore, the aim of the present study was to prepare antacid tablets from Cuttlefish bone and assessment of its antacid properties. Methods: 24 different formulations of cuttlefish bone were prepared by direct compression using different fillers (starch, cellulose, lactose, and mixture of those) in different ratios of the drug. Characterization of powders and tablets was done on all formulations and marketed dosage forms (calcium carbonate and Al-Mg). Results: Weight uniformity, hardness, and friability of all formulations were in acceptable range. Tablets prepared by calcined cuttlebone disintegrated in longer time due to their higher hardness which were mostly higher than 5 Kg. Also, disintegration time of formulations 50-50 (lower dose of cuttlebone) was less than other tablets (2 minutes or less). Results of antacid capacity showed that formulations 90-10 and 80-20 raise the acidic pH of the medium above 7.5, which were the same as or more than the capacity of the marketed tablets. Conclusion: Tablets were prepared by 90 or 80 of either calcined or non-calcined cuttlebone showed the highest antacid capacity. © 2018 The Authors.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Bavarsad, N.; Nanotechnology Research Center, Ahvaz Jundishapur University of Medical SciencesIran; email:
Uncontrolled Keywords: Antacid Cuttlebone pH Tablet aluminum magnesium hydroxide calcium carbonate cellulose lactose natural product starch Article bone structure chemical analysis cuttlefish drug dosage form drug formulation nonhuman powder flow tablet disintegration time tablet friability tablet hardness tablet weight
Subjects: QU Biochemistry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 08 May 2020 14:42
Last Modified: 08 May 2020 14:42

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