Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence

Nasimi Doost Azgomi, R. and Zomorrodi, A. and Nazemyieh, H. and Fazljou, S. M. B. and Sadeghi Bazargani, H. and Nejatbakhsh, F. and Moini Jazani, A. and Ahmadi Asrbadr, Y. (2018) Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence. BioMed Research International, 2018.

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Introduction. Withania somnifera (WS) also known as ashwagandha is a well-known medicinal plant used in traditional medicine in many countries for infertility treatment. The present study was aimed at systemically reviewing therapeutic effects of WS on the reproductive system. Methods. This systematic review study was designed in 2016. Required data were obtained from PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, Web of Knowledge, Web of Science, and manual search of articles, grey literature, reference checking, and expert contact. Results. WS was found to improve reproductive system function by many ways. WS extract decreased infertility among male subjects, due to the enhancement in semen quality which is proposed due to the enhanced enzymatic activity in seminal plasma and decreasing oxidative stress. Also, WS extract improved luteinizing hormone and follicular stimulating hormone balance leading to folliculogenesis and increased gonadal weight, although some animal studies had concluded that WS had reversible spermicidal and infertilizing effects in male subjects. Conclusion. WS was found to enhance spermatogenesis and sperm related indices in male and sexual behaviors in female. But, according to some available evidences for spermicidal features, further studies should focus on the extract preparation method and also dosage used in their study protocols. © 2018 Ramin Nasimi Doost Azgomi et al.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Zomorrodi, A.; Department of Urology, Emam Reza Hospital, Tabriz University of Medical SciencesIran; email: Dr-zomorrodi@yahoo.com
Uncontrolled Keywords: 4 aminobutyric acid alkaloid fatty acid flavonoid follitropin lactone luteinizing hormone neurotransmitter saponin Withania somnifera extract plant extract Withania somnifera enzyme activity genital system gonad human male infertility nonhuman ovary follicle development oxidative stress Review seminal plasma sexual behavior sperm quality spermatogenesis systematic review animal chemistry drug effect medicinal plant phytotherapy procedures Withania Animals Genitalia Humans Plant Extracts Plants, Medicinal
Subjects: WQ Obstetrics
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 08 May 2020 14:33
Last Modified: 08 May 2020 14:33
URI: http://eprints.mums.ac.ir/id/eprint/17449

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