Plantago major protects against cisplatin-induced renal dysfunction and tissue damage in rats

Parhizgar, S. and Hosseinian, S. and Soukhtanloo, M. and Bideskan, A. E. and Hadjzadeh, M. A. R. and Shahraki, S. and Noshahr, Z. S. and Heravi, N. E. and Haghshenas, M. and Rad, A. K. (2018) Plantago major protects against cisplatin-induced renal dysfunction and tissue damage in rats. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 29 (5). pp. 1057-1064.

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Abstract

The aim of the present study was to determine the effect of Plantago major (P. major) on cisplatin-induced kidney injury in the rat. Cisplatin was injected on the 6th day of the experiment. Animals were treated with P. major extract (300, 600, and 1200 mg/kg) and Vitamin E for five days before and two weeks after cisplatin administration. Cisplatin caused a significant decrease in glomerular filtration rate (GFR), urine osmolarity, and urinary excretion rate of potassium, but significant increase in the kidney index and histological damage compared with the control group. Administration of Vitamin E and P. major (300 and 600 mg/kg) significantly increased GFR compared to cisplatin group. Furthermore, urine osmolarity in Vitamin E and P. major (600 mg/kg) groups were significantly elevated compared to the cisplatin group. P. major (600 mg/kg) significantly increased the urinary excretion rate of potassium compared with cisplatin group. Furthermore, all doses of P. major and Vitamin E significantly attenuated the percentage of kidney tissue damage compared to the cisplatin group. However, only P. major (600 mg/kg) and Vitamin E treated rats showed a significant reduction in the kidney index. This study revealed that P. major extract in a dose-dependent manner provides protection against renal damage induced by cisplatin.

Item Type: Article
Additional Information: Export Date: 16 February 2020
Uncontrolled Keywords: alpha tocopherol biological marker cisplatin plant extract animal cell protection chemistry disease model dose response drug effect glomerulus filtration rate isolation and purification kidney kidney disease male osmolarity pathology pathophysiology Plantago urine Wistar rat Animals Biomarkers Cytoprotection Disease Models, Animal Dose-Response Relationship, Drug Glomerular Filtration Rate Kidney Diseases Osmolar Concentration Plant Extracts Rats, Wistar Vitamin E
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 07 May 2020 09:32
Last Modified: 07 May 2020 09:32
URI: http://eprints.mums.ac.ir/id/eprint/17460

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