Current concepts on immunopathogenesis of hepatitis B virus infection

Peeridogaheh, H. and Meshkat, Z. and Habibzadeh, S. and Arzanlou, M. and Shahi, J. M. and Rostami, S. and Gerayli, S. and Teimourpour, R. (2018) Current concepts on immunopathogenesis of hepatitis B virus infection. Virus Research, 245. pp. 29-43.

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Abstract

Hepatitis B virus (HBV) infection is a leading cause of liver damage and hepatic inflammation. Upon infection, effective antiviral responses by CD8+ T cells, CD4+ T cells, Natural killer (NK) cells, and monocytes can lead to partial or complete eradication of the viral infection. To date, many studies have shown that the production of inhibitory cytokines such as Interleukin 10 (IL-10), Transforming growth factor beta (TGF-β), along with dysfunction of the dendritic cells (DCs), and the absence of efficient innate immune responses could lead to T cell exhaustion, development of persistent infection, and inability to eradicate the viral infection from liver. Understanding the immunopathogenesis of the virus could be useful in providing further insights toward novel strategies in the eradication of HBV infection. © 2017 Elsevier B.V.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 CODEN: VIRED Correspondence Address: Teimourpour, R.; Department of Microbiology, School of Medicine, Ardabil University of Medical SciencesIran; email: r.teymourpour@gmail.com
Uncontrolled Keywords: Dendritic cells Monocytes Virus alpha interferon antivirus agent circular DNA hepatitis B vaccine immunosuppressive agent interleukin 10 interleukin 21 lymphotoxin beta receptor nucleoside analog nucleotide derivative peginterferon alpha programmed death 1 ligand 1 recombinant granulocyte macrophage colony stimulating factor recombinant interleukin 12 small interfering RNA sulfonamide transforming growth factor beta IL10 protein, human acute hepatitis B adaptive immunity antibody response CD4+ T lymphocyte CD8+ T lymphocyte chronic hepatitis B dendritic cell disease eradication DNA cleavage epigenetics genetics genotype hepatitis B human immune response immunopathogenesis immunotherapy innate immunity liver cell carcinoma monocyte natural killer cell natural killer T cell nonhuman persistent infection priority journal regulatory T lymphocyte Review T lymphocyte Th17 cell virology agonists biosynthesis clonal anergy drug effect gene expression regulation Hepatitis B virus immunology liver mass immunization pathogenicity pathology procedures synthesis virus load Antiviral Agents Hepatitis B Vaccines Hepatitis B, Chronic Humans Immunity, Innate Interleukin-10 Killer Cells, Natural Mass Vaccination T-Lymphocytes Viral Load
Subjects: WC Communicable Diseases
QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 May 2020 03:35
Last Modified: 09 May 2020 03:35
URI: http://eprints.mums.ac.ir/id/eprint/17462

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