A STROBE compliant observational study on trace elements in patients with ulcerative colitis and their relationship with disease activity

Poursadegh, F. and Ahadi, M. and Vosoughinia, H. and Salehi, M. and Namdar, A. B. and Farzanehfar, M. R. and Memar, B. and Ziaolhagh, R. (2018) A STROBE compliant observational study on trace elements in patients with ulcerative colitis and their relationship with disease activity. Medicine (United States), 97 (52).

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Abstract

Nutritional deficiencies and malnutrition are considered to be related to ulcerative colitis (UC); however, the association between serum levels of micronutrients and UC is not well known. This study aimed to evaluate the serum levels of micronutrients in UC patients and investigate their association with disease activity. This cross-sectional study was conducted on UC patients visiting the Department of Gastroenterology at 3 different teaching hospitals between January 2016 and January 2017. UC activity was measured based on Truelove and Witts' severity index and guidelines for colonoscopy. A healthy gender- and age-matched group was also selected. Serum levels of zinc, copper, selenium, ceruloplasmin, albumin, and total protein were compared between the 2 groups of UC patients and healthy subjects using independent-samples t test. Also, the association between serum levels of micronutrients and UC activity was assessed by using Pearson and Spearman correlation coefficient tests. The data were analyzed by SPSS version 21, considering P .05 as the statistical significance level. Overall, 112 (54 male and 58 female) individuals with the mean age of 34.6 years were studied in the 2 groups of UC patients (n = 56) and healthy subjects (n = 56). The 2 groups were homogeneous in terms of age, gender, marital status, place of residence, and educational level (P >.05). The serum levels of total protein (6.41 ± 1.1 vs 7.41 ± 0.4 g/dL; P = .0001), albumin (4.72 ± 1.1 vs 5.19 ± 0.28 g/dL; P = .0001), zinc (679 ± 62 vs 1055 ± 156 mg/L; P = .0001), and selenium (81.85 ± 6.4 vs 108.4 ± 12.98 micg/L; P = .0001) were significantly lower in the UC patients. The serum level of copper did not differ significantly between the 2 groups (P = .1). Considering the simultaneous reduction in nutritional criteria in the UC patient group, malnutrition appears to be a factor affecting micronutrient deficiency in patients with UC. Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 CODEN: MEDIA Correspondence Address: Ahadi, M.; Administration Office of Mashhad University of Medical Sciences, Knowledge and Health City, End of Shahid Fakouri Blvd, Iran; email: AhadiM@mums.ac.ir
Uncontrolled Keywords: Colitis Inflammatory bowel disease Micronutrient Trace elements Ulcerative albumin ceruloplasmin copper selenium trace element zinc plasma protein serum albumin adult Article blood sampling colonoscopy comparative study cross-sectional study data analysis software disease activity disease association disease severity female human male medical history nutritional deficiency nutritional status observational study physical examination priority journal teaching hospital ulcerative colitis blood complication deficiency nonparametric test severity of illness index Blood Proteins Colitis, Ulcerative Cross-Sectional Studies Humans Statistics, Nonparametric
Subjects: WI Digestive System
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 07 May 2020 06:45
Last Modified: 07 May 2020 06:45
URI: http://eprints.mums.ac.ir/id/eprint/17468

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