Endoscopic correction of vesicoureteral reflux in children

Rahimi, M. M. and Nazarbaghi, S. and Valizadeh, R. and Fakour, S. and Haghmoradi, M. (2018) Endoscopic correction of vesicoureteral reflux in children. Journal of Renal Injury Prevention, 7 (2). pp. 89-93.

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Introduction: Dextranomer/hyaluronic (Dx/HA) acid is the only tissue-augmenting agent approved by the Food and Drug Administration (FDA) for the vesicoureteral reflux (VUR) treatment. Objectives: We aimed to evaluate short-term outcomes of the Dx/HA in patients who had undergone subureteric injection. Patients and Methods: In this study, 30 patients with VUR diagnosis who had indications for open surgery were enrolled in the study. Patients underwent subureteric Dx/HA injection. Additionally patients underwent a one-year follow up period, subsequently. Follow up included urine analysis, urine cultures and kidney and urinary tract ultrasonography study. Results: Of a total 30 patients, 8 patients (27) were male and 22 patients (73) were female. The mean age of patients was 25.19 ± 0.70 months. Postoperative VUR resolution was observed in 28 patients (93.3). Moreover, during one year follow up, urinary tract infection (UTI) was not reported in patients. However, recurrent VUR was detected in 8 patients (27) during ultrasonography follow up. Analysis showed no significant difference of recurrence in VUR between males and females (P = 0.285) and VUR severity (P = 0.1). There was a significant relationship between recurrent UTI history before intervention and VUR recurrence after subureteric injection (P = 0.007). Conclusion: Dx/HA acid subureteric injection provides acceptable resolution rate among VUR patients, but its biodegradability causes VUR recurrence during one-year follow up. © 2018 The Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Fakour, S.; Urmia University of Medical SciencesIran; email: sanam.fakour2000@gmail.com
Uncontrolled Keywords: Dextranomer Subureteric injection Urinary tract infection Vesicoureteral reflux
Subjects: WI Digestive System
WS Pediatrics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 06 May 2020 13:11
Last Modified: 06 May 2020 13:11
URI: http://eprints.mums.ac.ir/id/eprint/17475

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