Ultrasmall superparamagnetic Fe 3 O 4 nanoparticles: Honey-based green and facile synthesis and in vitro viability assay

Rasouli, E. and Basirun, W. J. and Rezayi, M. and Shameli, K. and Nourmohammadi, E. and Khandanlou, R. and Izadiyan, Z. and Sarkarizi, H. K. (2018) Ultrasmall superparamagnetic Fe 3 O 4 nanoparticles: Honey-based green and facile synthesis and in vitro viability assay. International Journal of Nanomedicine, 13. pp. 6903-6911.

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Introduction: In the present research, we report a quick and green synthesis of magnetite nanoparticles (Fe 3 O 4 -NPs) in aqueous solution using ferric and ferrous chloride, with different percentages of natural honey (0.5, 1.0, 3.0 and 5.0 w/v) as the precursors, stabilizer, reducing and capping agent, respectively. The effect of the stabilizer on the magnetic properties and size of Fe 3 O 4 -NPs was also studied. Methods: The nanoparticles were characterized by X-ray diffraction (XRD) analysis, field emission scanning electron microscopy, energy dispersive X-ray fluorescence, transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy. Results: The XRD analysis indicated the presence of pure Fe 3 O 4 -NPs while the TEM images indicated that the Fe 3 O 4 -NPs are spherical with a diameter range between 3.21 and 2.22 nm. The VSM study demonstrated that the magnetic properties were enhanced with the decrease in the percentage of honey. In vitro viability evaluation of Fe 3 O 4 -NPs performed by using the MTT assay on the WEHI164 cells demonstrated no significant toxicity in higher concentration up to 140.0 ppm, which allows them to be used in some biological applications such as drug delivery. Conclusion: The presented synthesis method can be used for the controlled synthesis of Fe 3 O 4 -NPs, which could be found to be important in applications in biotechnology, biosensor and biomedicine, magnetic resonance imaging and catalysis. © 2018 Rasouli et al.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Basirun, W.J.; Department of Chemistry, Faculty of Science, University of Malaya, Wilayah Persekutuan Kuala LumpurMalaysia; email: jeff@um.edu.my
Uncontrolled Keywords: Fe 3 O 4 nanoparticles Green synthesis Honey In vitro Magnetic properties MTT assay Transmission electron microscopy Viability Wehi164 cells drug ferric chloride ferrous chloride magnetite nanoparticle reducing agent stabilizing agent superparamagnetic iron oxide nanoparticle ultrasmall superparamagnetic iron oxide ferric ion ferric oxide aqueous solution Article cell viability assay concentration (parameters) controlled study drug delivery system energy dispersive X ray fluorescence spectroscopy field emission scanning electron microscopy Fourier transform infrared spectroscopy green chemistry in vitro study magnetometry particle size synthesis vibrating sample magnetometry WEHI-164 cell line X ray diffraction cell survival chemistry fibrosarcoma pathology tumor cell culture Ferric Compounds Magnetite Nanoparticles Tumor Cells, Cultured
Subjects: QT physiology
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 06 May 2020 12:06
Last Modified: 06 May 2020 12:06
URI: http://eprints.mums.ac.ir/id/eprint/17488

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