Insight into DNA protection ability of medicinal herbs and potential mechanisms in hydrogen peroxide damages model

Sabahi, Z. and Soltani, F. and Moein, M. (2018) Insight into DNA protection ability of medicinal herbs and potential mechanisms in hydrogen peroxide damages model. Asian Pacific Journal of Tropical Biomedicine, 8 (2). pp. 120-129.

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Abstract

DNA damage is one of the most important consequences of oxidative stress in the cells. If DNA repair is unable to modify these inducible DNA damages, genomic instability may lead to mutation, cancer, aging and many other diseases. Single cell gel electrophoresis or comet assay is a common and versatile method to quantify these types of DNA damages. DNA damages induced by hydrogen peroxide (H2O2) are one of the proper models for measurement of protective ability of different compounds. So the main aim of this review is to provide an overview about protection ability of medicinal plants and their potential mechanism against H2O2 induced DNA damages. In this review, relevant researches on the effect of medicinal plants on DNA damages induced by H2O2 and possible molecular mechanisms are discussed. It seems that, medicinal plants are considered as therapeutic key factors to protect DNA from consequences caused by oxidative stress. Sufficient in vitro evidences introduce them as DNA protective agents through different mechanisms including antioxidant activity and some other cellular mechanisms. Moreover, in order to correlate the antigenotoxicity effects with their potential antioxidant property, most of medicinal plants were evaluated in term of antioxidant activity using standard methods. This review highlights the preventive effects of herbal medicine against oxidative DNA damages as well as provides rational possibility to engage them in animal studies and future clinical investigations. ©2018 Asian Pacific Journal of Tropical Biomedicine Produced by Wolters Kluwer-Medknow.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Moein, M.; Medicinal Plants Processing Research Center, Shiraz University of Medical SciencesIran; email: mrmoein@sums.ac.ir
Uncontrolled Keywords: Comet assay DNA damage Herbal medicine Hydrogen peroxide Single cell gel electrophoresis antioxidant DNA flavonoid hydroxyl radical protective agent reactive oxygen metabolite antigenotoxicity effect antioxidant activity cell protection DNA protection drug activity free radical scavenging assay herb human lipid peroxidation nonhuman nucleic acid structure, metabolism and function oxidative stress priority journal Review
Subjects: QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 06 May 2020 13:00
Last Modified: 06 May 2020 13:00
URI: http://eprints.mums.ac.ir/id/eprint/17497

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