Prognostic significance of fluorine-18 fluorodeoxyglucose positron emission tomography in anal squamous cell carcinoma: A systematic review and a meta-analysis

Sadeghi, R. and Harsini, S. and Qodsi Rad, M. A. and Dabbagh, V. R. and Treglia, G. (2018) Prognostic significance of fluorine-18 fluorodeoxyglucose positron emission tomography in anal squamous cell carcinoma: A systematic review and a meta-analysis. Contrast Media and Molecular Imaging, 2018.

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Abstract

Purpose. Prognostic significance of fluorine-18 fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET) in anal squamous cell carcinoma (SCC) has been evaluated in several studies; however, the results seem to be controversial and no consensus exists about its predictive capability. The current meta-analysis was carried out to comprehensively investigate the prognostic significance of 18 F-FDG-PET parameters in patients with anal SCC. Methods. A comprehensive literature search of PubMed/MEDLINE and Scopus databases was performed to retrieve pertinent articles published until August 5th 2018, concerning the prognostic significance of 18 F-FDG-PET in patients with anal SCC. No language restriction was used. Several prognostic factors were reported for progression-free survival (PFS) and overall survival (OS) including pretreatment maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), inguinal nodal uptake, and metabolic response to therapy. Results. Eleven studies (741 patients) were included. The pooled hazard ratio (HR) for the probability of PFS was 5.36 (95 confidence interval (95 CI): 3.12-9.21, p<0.001) for metabolic response to therapy and 1.98 (95 CI: 1.26-3.12, p=0.003) for SUVmax. The pooled HR for the probability of OS was 5.87 (3.02-11.39, p<0.0001) for metabolic response to therapy. On the other hand, the study revealed that the pooled HRs of MTV and inguinal nodal uptake for PFS were 1.56 (95 CI: 0.96-2.53, p=0.072) and 1.79 (95 CI: 1-3.21, p=0.051), respectively. Conclusions. Our findings propose that some 18 F-FDG-PET parameters could serve as prognostic indicators in anal SCC, but further larger studies are needed in this setting. © 2018 Ramin Sadeghi et al.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Treglia, G.; Clinic of Nuclear Medicine and PET/CT Center, Ente Ospedaliero Cantonale, Oncology Institute of Southern SwitzerlandSwitzerland; email: giorgiomednuc@libero.it
Uncontrolled Keywords: fluorodeoxyglucose f 18 anus carcinoma cancer prognosis cancer survival confidence interval data base data extraction hazard ratio human inguinal nodal uptake maximum standardized uptake value metabolic tumor volume metabolism oncological parameters overall survival positron emission tomography priority journal probability progression free survival publishing quality control Review squamous cell carcinoma systematic review treatment response anus tumor diagnostic imaging meta analysis mortality procedures prognosis survival analysis tumor volume Anus Neoplasms Carcinoma, Squamous Cell Fluorodeoxyglucose F18 Humans Positron-Emission Tomography Tumor Burden
Subjects: WI Digestive System
WN Radiology . Diagnostic Imaging
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 05 May 2020 03:27
Last Modified: 05 May 2020 03:27
URI: http://eprints.mums.ac.ir/id/eprint/17501

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