Comparison of ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after Orthognathic surgeries: A triple blind randomized controlled trial

Samieirad, S. and Sharifian-Attar, A. and Eshghpour, M. and Mianbandi, V. and Shadkam, E. and Hosseini-Abrishami, M. and Hashemipour, M. S. (2018) Comparison of ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after Orthognathic surgeries: A triple blind randomized controlled trial. Medicina Oral Patologia Oral y Cirugia Bucal, 23 (6). e767-e776.

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Comparison of ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after Orthognathic surgeries A triple blind randomized controlled trial.pdf

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Abstract

Background: The aim of this randomized controlled triple blind trial was to compare the efficacy of clonidine with dexamethasone versus ondansetron with dexamethasone for postoperative pain, nausea and vomiting prevention in orthognathic surgery patients. Material and Methods: In this clinical trial study, 30 consecutive patients with skeletal class III deformities were candidates for orthognathic surgery in Qaem hospital, Mashhad University of medical sciences, Mashhad, Iran from March to November 2017. These subjects were randomly assigned to two equal number groups, ondansetron or clonidine. Patients received either oral ondansetron 8mg or oral clonidine 150μg as premedication, 1 hour before the surgery (both dissolved in 20 cc of water). Also both groups received intravenous dexamethasone 8mg (1 hour preoperatively and every 4 hours intraoperatively). Results: In this study, a total of 30 patients (14 males and 16 females) with a mean age of 23.9 ± 3.9 were investigat­ed. The incidence of postoperative nausea in women was more than men (p=0.003), also the correlation between the incidence of PON and the surgery duration ≥ 3 hours was statistically significant (p = 0.050). The frequency of postoperative nausea (PON) in the ondansetron group was less than clonidine (53.3 vs 73.3 respectively). There was no postoperative vomiting (POV) in the ondansetron group, but 6.7 of cases in clonidine group suffered POV. Post-operative nausea in ondansetron group occurred significantly later than clonidine (525.0±233.2 vs 100.0±34.0 min; p <0.001). On the other hand, the incidence time of post-operative severe pain or in other word the analgesia time in clonidine group was significantly more than ondansetron one (875/0±68/5 vs 614.3±159.1 min; p <0.001). Conclusion: Ondansetron with dexamethasone premedication was more effective in controlling PONV after orthognathic surgery compared to clonidine with dexamethasone group. © Medicina Oral S. L. C.I.F.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Hashemipour, M.-S.; Department of Oral Medicine, School of Dentistry, Kerman University of Medical SciencesIran; email: mshashemipour@yahoo.com
Uncontrolled Keywords: Clonidine Ondansetron Postoperative nausea and vomiting antiemetic agent atracurium besilate atropine cefazolin dexamethasone lidocaine metoclopramide midazolam neostigmine paracetamol propofol remifentanil analgesic agent adult analgesia anesthetic recovery antibiotic therapy Article body mass capnometry clinical article clinical trial comparative study controlled study correlation analysis drug effect electrocardiography female genioplasty heart rate human Le Fort I osteotomy male mandible fracture mean arterial pressure nausea and vomiting operation duration orthognathic surgery osteotomy postoperative care postoperative pain premedication preoperative care prevalence prophylaxis pulse oximetry randomized controlled trial visual analog scale young adult adolescent double blind procedure treatment outcome Analgesics Antiemetics Double-Blind Method Humans Orthognathic Surgical Procedures Pain, Postoperative
Subjects: WI Digestive System
WU Dentistry. Oral surgery
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 05 May 2020 02:45
Last Modified: 05 May 2020 02:45
URI: http://eprints.mums.ac.ir/id/eprint/17517

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