Investigation of melanoma-associated antigen A4 cancer/testis antigen clinical relevance in esophageal squamous cell carcinoma

Sani, S. and Forghanifard, M. and Sharifi, N. and Bidokhti, M. and Bagherpoor, A. and Abbaszadegan, M. (2018) Investigation of melanoma-associated antigen A4 cancer/testis antigen clinical relevance in esophageal squamous cell carcinoma. Journal of Cancer Research and Therapeutics, 14 (5). pp. 1059-1064.

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Abstract

Background: Esophageal squamous cell carcinoma (ESCC) is considered as the seventh most common cancer worldwide, and the second prevalent malignancy in the north of Iran. A subfamily group of tumor-specific antigens, commonly specified as cancer/testis antigens (CTAs), are expressed restrictedly in testis, ovary, and placenta. Melanoma-associated antigen A4 (MAGEA4) as a CTA is overexpressed in a variety of cancers. Expressional analysis of MAGEA4 protein in ESCC may be useful to investigate its clinical relevance leading to effective improvements in ESCC diagnosis and treatment. Materials and Methods: Fifty-six ESCC patients with no preoperative therapeutic circumstance such as radiotherapy or chemotherapy were analyzed to explore the protein expression level of MAGEA4 using immunohistochemistry assay. Results: MAGEA4 overexpression was detected in 66 of ESCC samples showing strong nuclear and cytoplasmic staining compared to the normal epithelium. There were significant correlations between MAGEA4 protein expression and depth of tumor invasion (P = 0.019), and the number of involved lymph nodes (P = 0.045). Conclusion: Because of the significant correlation of MAGEA4 and indices of poor prognosis, the role of this CTA may be confirmed in ESCC aggressiveness and metastasis. Therefore, MAGEA4 may be a promising therapeutic candidate for suppressing ESCC aggressiveness. © 2018 Medknow Publications. All Rights Reserved.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Abbaszadegan, M.; Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Bu-Ali Square, Iran; email: abbaszadeganmr@mums.ac.ir
Uncontrolled Keywords: Cancer-testis antigens esophageal squamous cell carcinoma immunohistochemistry melanoma-associated antigen A4 tumor marker cancer testis antigen melanoma antigen 4 MAGEA4 protein, human tumor antigen tumor protein adult aged antigen expression Article cancer prognosis cell nucleus controlled study cytoplasm human human tissue lymph node metastasis major clinical study metastasis preoperative period protein expression level tumor invasion upregulation cancer staging disease free survival esophagus tumor female gene expression regulation genetics male middle aged pathology prognosis squamous cell carcinoma very elderly Aged, 80 and over Antigens, Neoplasm Biomarkers, Tumor Carcinoma, Squamous Cell Disease-Free Survival Esophageal Neoplasms Gene Expression Regulation, Neoplastic Humans Lymphatic Metastasis Neoplasm Proteins Neoplasm Staging
Subjects: WI Digestive System
QU Biochemistry
QW Microbiology and Immunology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 05 May 2020 02:49
Last Modified: 05 May 2020 02:49
URI: http://eprints.mums.ac.ir/id/eprint/17518

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